Results 61 to 70 of about 538,572 (295)

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

ABOUT “LEGITIMIZATION” OF NUMERICAL MODELLING OF WIND IMPACTS ON BUILDINGS AND STRUCTURES IN DESIGN CODES

International Journal for Computational Civil and Structural Engineering, 2019
The distinctive paper is detoded to problem of “legitimization” of numerical modelling of wind loads and impacts on buildings and structures. General information about computational fluid dynamics (CFD) and its development prospects is presented.
Alexander Belostotsky, Pavel Akimov, Irina Afanasyeva   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The promised territories: the production of branded housing projects in contemporary Turkey [PDF]

, 2016
Cities in Turkey, following the neoliberal restructuring of the country, have undergone a process of transformation in the last decade at a greater pace than experienced in previous periods.
Serin, Bilge
core   +3 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Ultrasonic field-assisted metal additive manufacturing (U-FAAM): Mechanisms, research and future directions

Ultrasonics Sonochemistry
Metal additive manufacturing (AM) is a disruptive technology that provides unprecedented design freedom and manufacturing flexibility for the forming of complex components.
Xuekai Li, Wei Wang, Yihong Wu, Donghu Zhou, Huijun Kang, Enyu Guo, Jiehua Li, Zongning Chen, Yanjin Xu, Tongmin Wang   +9 more
doaj   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Remote Sensing of Chiral Signatures on Mars [PDF]

, 2012
We describe circular polarization as a remote sensing diagnostic of chiral signatures which may be applied to Mars. The remarkable phenomenon of homochirality provides a unique biosignature which can be amenable to remote sensing through circular ...
Barron, Carpenter, Cockell, Cockell, Costerton, Davey, Degtiarev, Frank Robb, Hall-Stoodley, Hough, James H. Hough, Kelly, Kemp, Landis, Litchfield, Ludmilla Kolokolova, Malin, Martin, Mumma, Norris, Osterloo, Purdie, Sazonov, Shapiro, Sparks, Sparks, Sparks, Thomas A. Germer, Wierzchos, William Sparks, Zahnle   +30 more
core   +2 more sources

Distinct Properties and Advantages of a Novel Peroxisome Proliferator-Activated Protein γ Selective Modulator [PDF]

Molecular Endocrinology, 2003
Antidiabetic thiazolidinediones (TZDs) and non-TZD compounds have been shown to serve as agonists of the peroxisome proliferator-activated receptor gamma (PPARgamma). Here, we report the identification and characterization of a novel non-TZD selective PPARgamma modulator (nTZDpa). nTZDpa bound potently to PPARgamma with high selectivity vs.
Joel P, Berger, Ann E, Petro, Karen L, Macnaul, Linda J, Kelly, Bei B, Zhang, Karen, Richards, Alex, Elbrecht, Bruce A, Johnson, Gaochao, Zhou, Thomas W, Doebber, Chhabi, Biswas, Mona, Parikh, Neelam, Sharma, Michael R, Tanen, G Marie, Thompson, John, Ventre, Alan D, Adams, Ralph, Mosley, Richard S, Surwit, David E, Moller   +19 more
openaire   +2 more sources

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source