Results 51 to 60 of about 535,496 (298)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Methodological approaches to risk assessment of real investment projects

MATEC Web of Conferences, 2018
Risk management is impossible without systematically assessing the level of significance of the risks identified in the project. Within the scope of the paper, the distinctive features of various qualitative and quantitative methods for assessing the ...
Bogomolova Ekaterina
doaj   +1 more source

Bioinspired Flexible and Programmable Negative Stiffness Mechanical Metamaterials

Advanced Intelligent Systems, 2023
Energy‐absorbing materials are widely used under certain high‐frequency scenarios, such as cargo packaging or sport protection. Though negative stiffness mechanical metamaterials have many distinctive advantages, fairly low strength and poor specific ...
Xiaojun Tan, Yifeng Li, Lianchao Wang, Kaili Yao, Qingxiang Ji, Bing Wang, Vincent Laude, Muamer Kadic   +7 more
doaj   +1 more source

Remote Sensing of Chiral Signatures on Mars [PDF]

, 2012
We describe circular polarization as a remote sensing diagnostic of chiral signatures which may be applied to Mars. The remarkable phenomenon of homochirality provides a unique biosignature which can be amenable to remote sensing through circular ...
Barron, Carpenter, Cockell, Cockell, Costerton, Davey, Degtiarev, Frank Robb, Hall-Stoodley, Hough, James H. Hough, Kelly, Kemp, Landis, Litchfield, Ludmilla Kolokolova, Malin, Martin, Mumma, Norris, Osterloo, Purdie, Sazonov, Shapiro, Sparks, Sparks, Sparks, Thomas A. Germer, Wierzchos, William Sparks, Zahnle   +30 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

RISK MANAGEMENT IN THE IMPLEMENTATION OF INVESTMENT AND CONSTRUCTION PROJECTS

Вестник университета, 2017
The article examines the problem of risk management in the implementation of investment and construction projects, proposed a comprehensive classification of risks, as well as a risk management mechanism for construction organizations.
I. Sokol
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Enumerating Counter-Factual Type Error Messages with an Existing Type Checker (poster+demo) [PDF]

, 2014
The Hindley-Milner type system is a foundation for most statically typed functional programming languages, such as ML, OCaml and Haskell. This type system has many advantageous, but it does make type debugging hard: If a program is not well-typed, it ...
Chitil, Olaf, Tsushima, Kanae
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Modelling Grocery Retail Topic Distributions: Evaluation, Interpretability and Stability [PDF]

, 2020
Understanding the shopping motivations behind market baskets has high commercial value in the grocery retail industry. Analyzing shopping transactions demands techniques that can cope with the volume and dimensionality of grocery transactional data while
Manolopoulou, Ioanna, Musolesi, Mirco, O'sullivan, Jason, Prior, Rosie, Vega-Carrasco, Mariflor   +4 more
core   +1 more source