Results 141 to 150 of about 2,286,559 (387)

An empirical investigation of failing companies and their determinants using the hazard model in an emerging capital market [PDF]

open access: yes, 2005
The purpose of this study is to highlight the predictors of financial distress during the period 1990 to 2000. Previous studies highlight the inadequacies of the MDA and the log it models and suggest that a hazard model gives a more accurate result due ...
Abdullah, Nur Adiana Hiau   +1 more
core  

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

open access: yesAdvanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann   +26 more
wiley   +1 more source

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

open access: yesAdvanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li   +7 more
wiley   +1 more source

The relationship between distress tolerance and life satisfaction among young adults in Saudi Arabia

open access: yesFrontiers in Psychology
PurposeThis study examined the relationship between Distress Tolerance, defined as the individual’s ability to withstand psychological stress or endure negative emotions, and Life Satisfaction, the cognitive component of the individual’s subjective ...
Hala Abd Ellatif Elsayed   +1 more
doaj   +1 more source

The Risk-Adjusted Cost of Financial Distress [PDF]

open access: yes
In this paper we argue that risk-adjustment matters for the valuation of financial distress costs, since financial distress is more likely to happen in bad times.
Heitor Almeida, Thomas Philippon
core  

Long‐Term Effects of Xenotransplantation of Human Enteric Glia in an Immunocompetent Rat Model of Acute Brain Injury

open access: yesAdvanced Science, EarlyView.
Acute brain injuries are characterized by extensive tissue damage, resulting in debilitating deficits in patients. Despite considerable progress, cell‐based approaches have yet to identify an ideal candidate. This long‐term study explores the use of an untested cell source – human enteric glia – and a non‐invasive administration route – intranasal ...
Nina Colitti   +11 more
wiley   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

open access: yesAdvanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen   +4 more
wiley   +1 more source

Comparison of Nasal Non-invasive Ventilation Methods in Preterm Neonates with Respiratory Distress Syndrome [PDF]

open access: green, 2018
Shahfarhat Ahmad   +4 more
openalex   +1 more source

Home - About - Disclaimer - Privacy