Results 91 to 100 of about 1,301,602 (288)

Compositional competitiveness for distributed algorithms

open access: yes, 2003
We define a measure of competitive performance for distributed algorithms based on throughput, the number of tasks that an algorithm can carry out in a fixed amount of work. This new measure complements the latency measure of Ajtai et al., which measures
Aspnes, James, Waarts, Orli
core   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Distributed algorithms from arboreal ants for the shortest path problem. [PDF]

open access: yesProc Natl Acad Sci U S A, 2023
Garg S   +3 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Deep Reinforcement Learning Approaches for Sensor Data Collection by a Swarm of UAVs

open access: yesAdvanced Intelligent Systems
The number of applications that use IoT devices as a sensing platform is ever‐increasing. A major obstacle to the flexibility of these systems is the requirement for constant connectivity to the sensing devices, constraining the applications to scenarios
Thiago de Souza Lamenza   +2 more
doaj   +1 more source

AMADEUS: an adaptive multi-agent system to learn a user’s recurring actions in ambient systems

open access: yesAdvances in Distributed Computing and Artificial Intelligence Journal, 2012
Ambient systems are characterized by their dynamics and their huge complexity.An important issue in this field is their capability to provide a relevant behaviour in order to satisfy users involved.
Valérian GUIVARCH   +2 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Optimized byzantine fault tolerant algorithm for improving performance and security with trust values

open access: yesIET Blockchain
Blockchain is considered to be a promising technology due to its decentralization, open, and non tamperation. Nevertheless, the current blockchain system cannot replace traditional financial institutions because its performance and security indicators in
Linqing Xiao   +3 more
doaj   +1 more source

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