Results 71 to 80 of about 1,301,602 (288)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A Short Counterexample Property for Safety and Liveness Verification of Fault-tolerant Distributed Algorithms

, 2016
Distributed algorithms have many mission-critical applications ranging from embedded systems and replicated databases to cloud computing. Due to asynchronous communication, process faults, or network failures, these algorithms are difficult to design and
Abdulla P. A., Baier C., Bouajjani A., Charron-Bost B., Clarke E., Clarke E., Cohen E., De Moura L., Emerson E. A., Esparza J., Fisman D., Konnov I., Konnov I., Kroening D., Ongaro D., Pnueli A., Pnueli A., Rahli V., Vardi M. Y.   +18 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Formal and incremental construction of distributed algorithms: On the distributed reference counting algorithm

Theoretical Computer Science, 2006
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Cansell, Dominique, Méry, Dominique
openaire   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

A Framework for Distributed Evolutionary Algorithms [PDF]

, 2002
This paper describes the recently released DREAM (Distributed Resource Evolutionary Algorithm Machine) framework for the automatic distribution of evolutionary algorithm (EA) processing through a virtual machine built from large numbers of individual machines linked by standard Internet protocols.
Maribel García Arenas, Pierre Collet, A. E. Eiben, Márk Jelasity, Juan Julián Merelo Guervós, Ben Paechter, Mike Preuß, Marc Schoenauer   +7 more
openaire   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Distributed Approximation Algorithms for Weighted Shortest Paths

, 2014
A distributed network is modeled by a graph having $n$ nodes (processors) and diameter $D$. We study the time complexity of approximating {\em weighted} (undirected) shortest paths on distributed networks with a $O(\log n)$ {\em bandwidth restriction} on
Abram J., Demetrescu C., Lynch N. A., Santoro N.   +3 more
core   +1 more source

Distributed Grover's algorithm

Theoretical Computer Science
20pages, five figures, comments are ...
Daowen Qiu, Le Luo, Ligang Xiao
openaire   +2 more sources

Descriptive Combinatorics and Distributed Algorithms

Notices of the American Mathematical Society, 2022
This is a draft of an article to appear in the October 2022 issue of the Notices of the AMS. In this survey article we explore a fascinating area called descriptive combinatorics and its recently discovered connections to distributed algorithms -- a fundamental part of computer science that is becoming increasingly important in the modern era of ...
openaire   +2 more sources