Results 41 to 50 of about 3,487,111 (248)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Distributed Asymptotic Minimization of Sequences of Convex Functions by a Broadcast Adaptive Subgradient Method [PDF]

, 2011
We propose a non-hierarchical decentralized algorithm for the asymptotic minimization of possibly time-varying convex functions. In our method, each agent in a network has a private, local (possibly time-varying) cost function, and the objective is to ...
Renato L. G. Cavalcante, Jennings, Nick, Isao Yamada, Cavalcante, Renato L. G., Rogers, A, Alex Rogers, Nicholas R. Jennings, Rogers, Alex, Yamada, I, Jennings, N, Yamada, Isao, Cavalcante, RLG, Cavalcante, R.L.G., ロジャーズ, アレックス, ジェニングス, ニック, Jennings, N.R., Rogers, A., Yamada, I., ｶﾊﾞﾙｶﾝﾃ, ﾚﾅﾄ, 山田, 功, Cavalcante, Renato   +20 more
core   +2 more sources

ACapDS: An Energy-Efficient and Fault-Tolerant Distributed Capacitated Dominating Set Algorithm for Industrial IoT

IEEE Access
Design and analysis of energy-efficient and fault-tolerant dominating set (DS) algorithms are vital tasks for Industrial Internet of Things (IIoT) scenarios, as operational efficiency is a key objective in most industries.
Ozkan Arapoglu, Umut Can Cabuk, Orhan Dagdeviren, Moharram Challenger   +3 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Distributed Interval Synchronization

IEEE Access
In this paper we address the problem of using pairwise measures associated with the edges of a graph to obtain absolute consistent measures associated with the nodes. This problem is known in the literature as graph synchronisation.
Andrea Fusiello, Pier Luca Montessoro
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

08371 Summary – Fault-Tolerant Distributed Algorithms on VLSI Chips

, 2009
Chips was devoted to exploring whether the wealth of existing fault-tolerant distributed algorithms research can be utilized for meeting the challenges of future-generation VLSI chips.
Dolev, Shlomi, Ebergen, Jo, Charron-Bost, Bernadette, Schmid, Ulrich   +3 more
core   +1 more source