Results 91 to 100 of about 1,610,469 (333)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Distributed Robust Learning [PDF]

open access: yes, 2015
We propose a framework for distributed robust statistical learning on {\em big contaminated data}. The Distributed Robust Learning (DRL) framework can reduce the computational time of traditional robust learning methods by several orders of magnitude. We
Feng, Jiashi, Mannor, Shie, Xu, Huan
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Modeling Implicit Trust in Matrix Factorization-Based Collaborative Filtering

open access: yesApplied Sciences, 2019
Recommendation systems often use side information to both alleviate problems, such as the cold start problem and data sparsity, and increase prediction accuracy.
Yuyu Yuan, Ahmed Zahir, Jincui Yang
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Distributive Computability

open access: yes, 2003
This thesis presents a series of theoretical results and practical realisations about the theory of computation in distributive categories. Distributive categories have been proposed as a foundational tool for Computer Science in the last years, starting from the papers of R.F.C. Walters.
openaire   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Adaptive Energy-Aware Computation Offloading for Cloud of Things Systems

open access: yesIEEE Access, 2017
Cloud computing has become the de facto computing platform for application processing in the era of the Internet of Things (IoT). However, limitations of the cloud model, such as the high transmission latency and high costs are giving birth to a new ...
Yucen Nan   +6 more
doaj   +1 more source

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