Results 81 to 90 of about 3,355,993 (333)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Distributed computing to blockchain: Architecture, technology, and applications

, 2023
This chapter aims to explore the correlation between distributed computing and blockchain technology and deeply investigate the architecture and application of blockchain technology.
Wu, Jingyi, Gander, Anna Jia,, Lv, Zhihan, Chen, Dongliang   +3 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

MEFL: Meta-Equilibrize Federated Learning for Imbalanced Data in IoT

Entropy
In the Internet of Things (IoT), data distribution among diverse terminals exhibits substantial statistical heterogeneity. This imbalance can lead to skewness and accuracy degradation, ultimately affecting the generalization ability and robustness of ...
Jialu Tang, Yali Gao, Xiaoyong Li, Jia Jia   +3 more
doaj   +1 more source

Distributed computing methodology for training neural networks in an image-guided diagnostic application [PDF]

, 2006
Distributed computing is a process through which a set of computers connected by a network is used collectively to solve a single problem. In this paper, we propose a distributed computing methodology for training neural networks for the detection of ...
Plagianakos, V.P., Vrahatis, M.N., Magoulas, George D.   +2 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Detecting and Tracing i.i.d. Attacks in Networks With Any Number of Relays

IEEE Access, 2016
This paper investigates the detection and tracing problems in a multi-relay network, where a source wants to exchange the information with a destination through multiple potential malicious relay nodes.
Ruohan Cao, Shanguo Huang, Yueming Lu
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Analysis of Mobile Edge Computing for Vehicular Networks

Sensors, 2019
Vehicular ad-hoc Networks (VANETs) are an integral part of intelligent transportation systems (ITS) that facilitate communications between vehicles and the internet.
Zachary W. Lamb, Dharma P. Agrawal
doaj   +1 more source