Results 111 to 120 of about 1,610,469 (333)

A Semantic Data-Based Distributed Computing Framework to Accelerate Digital Twin Services for Large-Scale Disasters. [PDF]

Sensors (Basel), 2022
Kwon JW, Yun SJ, Kim WT.
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A Concept-Value Network as a Brain Model

NeuroSci
This paper suggests a statistical framework for describing the relations between the physical and conceptual entities of a brain-like model. Features and concept instances are put into context, where the paper suggests that features may be the electrical
Kieran Greer
doaj   +1 more source

Preparing Distributed Computing Operations for the HL-LHC Era With Operational Intelligence. [PDF]

Front Big Data, 2021
Di Girolamo A, Legger F, Paparrigopoulos P, Schovancová J, Beermann T, Boehler M, Bonacorsi D, Clissa L, Decker de Sousa L, Diotalevi T, Giommi L, Grigorieva M, Giordano D, Hohn D, Javůrek T, Jezequel S, Kuznetsov V, Lassnig M, Mageirakos V, Olocco M, Padolski S, Paltenghi M, Rinaldi L, Sharma M, Tisbeni SR, Tuckus N.   +25 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Efficient Ray Tracing of Large 3D Scenes for Mobile Distributed Computing Environments. [PDF]

Sensors (Basel), 2022
Seo W, Park S, Ihm I.
europepmc   +1 more source

A visualization tool for parallel and distributed computing using the Lilith framework [PDF]

, 1998
David A. Evensky, Ann C. Gentile, Pete Wyckoff   +2 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

YOU SHALL NOT COMPUTE on my Data: Access Policies for Privacy-Preserving Data Marketplaces and an Implementation for a Distributed Market using MPC [PDF]

, 2022
Stefan More, Lukas Alber
openalex   +1 more source