Results 71 to 80 of about 4,614,854 (360)

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

LVGG-IE: A Novel Lightweight VGG-Based Image Encryption Scheme

Entropy
Image security faces increasing challenges with the widespread application of computer science and artificial intelligence. Although chaotic systems are employed to encrypt images and prevent unauthorized access or tampering, the degradation that occurs ...
Mingliang Sun, Jie Yuan, Xiaoyong Li, Dongxiao Liu, Xinghai Wei   +4 more
doaj   +1 more source

Minimizing latency for secure distributed computing [PDF]

International Symposium on Information Theory, 2017
We consider the setting of a master server who possesses confidential data (genomic, medical data, etc.) and wants to run intensive computations on it, as part of a machine learning algorithm for example. The master wants to distribute these computations
Rawad Bitar, Parimal Parag, S. E. Rouayheb   +2 more
semanticscholar   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

A Survey of Deep Learning-Based Human Activity Recognition in Radar

Remote Sensing, 2019
Radar, as one of the sensors for human activity recognition (HAR), has unique characteristics such as privacy protection and contactless sensing. Radar-based HAR has been applied in many fields such as human–computer interaction, smart surveillance and ...
Xinyu Li, Yuan He, Xiaojun Jing
doaj   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Tessellated Distributed Computing

IEEE Transactions on Information Theory
The work considers the $N$-server distributed computing scenario with $K$ users requesting functions that are linearly-decomposable over an arbitrary basis of $L$ real (potentially non-linear) subfunctions. In our problem, the aim is for each user to receive their function outputs, allowing for reduced reconstruction error (distortion) $ε$, reduced ...
Ali Khalesi, Petros Elia
openaire   +2 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

On the Computational Security of a Distributed Key Distribution Scheme [PDF]

IEEE Transactions on Computers, 2008
The work of the first two authors was partially supported by the Spanish Ministry of Education and Science under Projects TSI2007-65406-C03-02 (“eAEGIS”) and CONSOLIDER CSD2007-00004 (“ARES”). The work of V. Daza was also supported by the Government of Catalonia under Grant 2005-SGR-00446. The work of J.
Daza, Vanesa, Herranz Sotoca, Javier, Sáez Moreno, Germán   +2 more
openaire   +5 more sources

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source