Results 141 to 150 of about 1,679,041 (317)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

A Distributed Approach to Efficient Model Predictive Control of Building HVAC Systems

, 2012
Model based predictive control (MPC) is increasingly being seen as an attractive approach in controlling building HVAC systems. One advantage of the MPC approach is the ability to integrate weather forecast, occupancy information and utility price ...
Putta, Vamsi, Zhu, Guangwei, Hu, Jianghai, Braun, James E., Kim, Donghun   +4 more
core  

Control flow speculation for distributed architectures [PDF]

, 2009
textAs transistor counts, power dissipation, and wire delays increase, the microprocessor industry is transitioning from chips containing large monolithic processors to multi-core architectures.
Ranganathan, Nitya
core  

Distributed state estimation for uncertain Markov-type sensor networks with mode-dependent distributed delays

, 2011
This the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2012 John Wiley & Sons, Ltd.In this paper, the distributed state estimation problem is investigated for a class of sensor ...
Zidong Wang, Liu, X, Liang, J, Wang, Z, Xiaohui Liu, Jinling Liang   +5 more
core   +1 more source

Twin3: Pluralistic Personal Digital Twins via Blockchain

IEEE Access
In the era of generative artificial intelligence (GAI), preserving personal authenticity is crucial for maintaining trust in online communities. Blockchain technology, with its unique blend of anonymity and data transparency, has facilitated the ...
Ming Hui Wen, Jerry Chun-Wei Lin
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Distributed control of motor circuits for backward walking in Drosophila. [PDF]

Nat Commun, 2020
Feng K, Sen R, Minegishi R, Dübbert M, Bockemühl T, Büschges A, Dickson BJ.   +6 more
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Distributed control of a fault tolerant modular multilevel inverter for direct-drive wind turbine grid interfacing

, 2012
Modular generator and converter topologies are being pursued for large offshore wind turbines to achieve fault tolerance and high reliability. A centralized controller presents a single critical point of failure which has prevented a truly modular and ...
Finney, Stephen J., Parker, Max, Ran, Li, Finney, Stephen, Parker, Max A.   +4 more
core   +1 more source