Results 51 to 60 of about 574,204 (308)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Mobile Collaborative Information System Using Distributed Database Architecture [PDF]

, 2009
This thesis examines the feasibility of communal information sharing between mobile devices using a distributed architecture for the underlying database topology, through research aimed at satisfying two primary objectives: i.
Cato, D. C.
core  

A web/grid portal implementation of BioSimGrid: a biomolecular simulation database

, 2004
The overall aim of the BioSimGrid project (www.biosimgrid.org) is to exploit the Grid infrastructure to enable comparative analysis of the distributed results of biomolecular simulations.
Essex, Jonathan, Sansom, Mark, Murdock, S, Jeffreys, Paul, Tai, K, B. Wu, Ng, Muan Hong, Tai, Kaihsu, K. Tai, J. Essex, Cox, Simon, Essex, Jonathan W., Sansom, Mark S.P., Murdock, Stuart, Cox, S, Dovey, M, Essex, J, Wu, Bing, S. Murdock, M. Dovey, Dovey, Matthew, Johnston, Steven, Fangohr, Hans, M.S.P. Sansom, Wu, B, P. Jeffreys, Ng, MH, Tai, Kaishu, Johnston, Steve, M.H. Ng, Jeffreys, P, S. Cox   +31 more
core   +1 more source

FEEDBACK ON A PUBLICLY DISTRIBUTED IMAGE DATABASE: THE MESSIDOR DATABASE

Image Analysis and Stereology, 2014
The Messidor database, which contains hundreds of eye fundus images, has been publicly distributed since 2008. It was created by the Messidor project in order to evaluate automatic lesion segmentation and diabetic retinopathy grading methods.
Etienne Decencière, Xiwei Zhang, Guy Cazuguel, Bruno Lay, Béatrice Cochener, Caroline Trone, Philippe Gain, Richard Ordonez, Pascale Massin, Ali Erginay, Béatrice Charton, Jean-Claude Klein   +11 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Research and implementation of asynchronous compaction mechanism of distributed database based on LSM-Tree

Xibei Gongye Daxue Xuebao
With the continuous development of information technology, distributed database has become a research hotspot. Due to the limit support for SQL and defects in transaction processing and consistency of distributed databases based on NoSQL architecture ...
DU Yide, LIU Wenjie
doaj   +1 more source

Enhanced adaptive partitioning in a distributed graph database

Journal of Information and Telecommunication, 2021
Nowadays, open-source graph databases do not include an inherent mechanism for data relocation that would be based on their usage. They often do not offer even appropriate monitoring that could help to make such a decision.
Lucie Svitáková, Michal Valenta, Jaroslav Pokorný   +2 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Allocation Fragments of the Distributed Database

Communications, 2003
The paper describes the distribution fragments of the database under a mathematical model with criterial function involving the influence of the Transaction and Concurrency proccesing in Database systems. The model could solve variants for replication of
Karol Matiasko
doaj   +1 more source