Results 71 to 80 of about 11,569,212 (291)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
XML Gateway for Heterogeneous Distributed Database Management Systems
JISR Management and Social Sciences & Economics, 2004 Conventional standalone application development paradigm is being transformed into multi-layered application development process. The main reason of transformation is the execution environment— particularly internetworking.
Aslam Parvez Memon, Muhammad Nadeem
doaj +1 more source
CDD/SPARCLE: the conserved domain database in 2020
Nucleic Acids Res., 2019 As NLM's Conserved Domain Database (CDD) enters its 20th year of operations as a publicly available resource, CDD curation staff continues to develop hierarchical classifications of widely distributed protein domain families, and to record conserved ...
Shennan Lu +16 more
semanticscholar +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Metadata queries for complex database systems [PDF]
, 2004 Federated Database Management Systems (FDBS) are very complex. Component databases can be heterogeneous, autonomous and distributed, accounting for these different characteristics in building a FDBS is a difficult engineering problem.
O'Connor, Gerald
core +1 more source
Record matching method based on local CON model in distributed database
Tongxin xuebao, 2011 For existing record matching methods needed much artificial participation of experts or depend on heuristic rules heavily,and they could not handle the problem of large-scale data,A record matching method based on the local CON model was proposed.The ...
LI Jiao1 +3 more
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
GEOBARN: A Practical Grid Geospatial Database System
Advances in Electrical and Computer Engineering, 2009 Recently, more and more geospatial data are generated and distributed with the promising data acquirement techniques like satellite imaging and digital cartography.
XIE, X., FANG, Y., HUANG, Z., PAN, M.
doaj +1 more source
The Design of a Distributed Database for Doctoral Studies Management [PDF]
This paper aims to create a system that manages doctoral school requirements. The management of doctoral school implies administration of information like PhD personal information, Supervisors, Teachers, and other information that may be useful.
Aurelian Razvan COSTIN +1 more
core