Results 101 to 110 of about 169,139 (307)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Design of filtering cable with defected conductor layer
Scientific ReportsElectrical cables, often referred to as ‘blood vessels’ and ‘nerves’ of the industry, play a vital role in the connection of electrical devices. However, traditional cables that lack distributed filtering functions are usually the primary coupling path ...
Yunan Han +3 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A Distributed Asynchronous Recursive Filtering Fusion Algorithm via DP-TBD
Leida xuebao, 2018 In this paper, we address target tracking problems by the use of multiple sensors via the Dynamic Programming (DP)-based Track-Before-Detect (TBD) method.
Li Yangyang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Distributed Fusion Receding Horizon Filtering in Linear Stochastic Systems
EURASIP Journal on Advances in Signal Processing, 2009 This paper presents a distributed receding horizon filtering algorithm for multisensor continuous-time linear stochastic systems. Distributed fusion with a weighted sum structure is applied to local receding horizon Kalman filters having different ...
Il Young Song +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Distributed Gaussian Mixture PHD Filtering Under Communication Constraints
IET Wireless Sensor SystemsThe Gaussian mixture probability hypothesis density (GM‐PHD) filter is an almost exact closed‐form approximation to the Bayes‐optimal multi‐target tracking algorithm.
Shiraz Khan +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Handling inconsistency in distributed data mining with paraconsistent logic [PDF]
, 2004 This paper addresses the problem of inconsistent rule subsets in distributed data mining. In this scenario, N rule subsets are independently discovered from N different data subsets. This can result in inconsistent rules – i.e.
Ferreira, Simone N.M. +2 more
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