Results 111 to 120 of about 819,025 (284)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Distributing Leadership [PDF]

open access: yes, 2009
{Excerpt} The prevailing view of leadership is that it is concentrated or focused. In organizations, this makes it an input to business processes and performance—dependent on the attributes, behaviors, experience, knowledge, skills, and potential of the ...
Serrat, Olivier
core   +1 more source

A comparison of distributed leadership readiness in elementary and middle schools [PDF]

open access: yes
The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf ...
Christy, Karyn M. J.
core   +1 more source

Realising distributed leadership through measurement for change. [PDF]

open access: yesFront Public Health, 2023
Watkins J, Muhamedjonova N, Holding PA.
europepmc   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Discourses of Distribution: Anchoring Educational Leadership to Practice [PDF]

open access: yes, 2009
The paper deals with the fashioning idea of distributed leadership and the related issue of education ecology democratization. The analysis of distributed leadership theories is carried on using two interpretative dimensions: discourses as regimes of ...
E. GRIMALDI   +2 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Leading careers education information advice and guidance (CEIAG) in secondary schools [PDF]

open access: yes, 2011
This report summarises the findings of a set of six case studies, undertaken during November 2010, which explored the effective leadership of careers education information advice and guidance (CEIAG) in a small sample of secondary schools in England ...
Barnes, Iain, Kent, Peter
core  

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