Results 31 to 40 of about 776,037 (264)

Determining Parental Factors for Clinical Trial Attrition in Pediatric Acute Lymphoblastic Leukemia

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Despite high enrollment rates on Children's Oncology Group (COG) protocols, attrition after initial consent is challenging, introducing bias and prolonging trial completion. While adult oncology literature has identified predictors of withdrawal, little is known about caregiver decision‐making for child participation in ...
Kimberly L. Stathas   +3 more
wiley   +1 more source

Security by Design in Hybrid Software Development: An Empirical Framework for Aligning Organizational Climate and Developer Behavior

open access: yesApplied Sciences
(1) Background: As security breaches rise, the “Security by Design” approach is imperative for software organizations. (2) Problem: A significant gap remains between declared security priorities and actual developer behavior.
Yizhaq Benbenisty, Irit Hadar, Gil Luria
doaj   +1 more source

Task Allocation in Distributed Software Development: A Systematic Literature Review

open access: yesComplexity, 2018
Distributed development is a constant need in the software industry. The allocation of tasks, in turn, is a critical activity for any project, especially in a distributed setting. Assigning a task to an individual or team can be done in a rigorous manner,
Marum Simão Filho   +3 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

An empirical study of local‐decision‐making‐based software customization in distributed development

open access: yesIET Software, 2021
Making a decision for the requirements of multi‐stakeholders is a key process, especially in distributed software development projects. Local decision‐making for requirements in distributed software development is really difficult to accomplish as well ...
Ahmed S. Ghiduk, Abdulrahman M. Qahtani
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

PlanetLab Europe as Geographically-Distributed Testbed for Software Development and Evaluation

open access: yesAdvances in Electrical and Electronic Engineering, 2015
In this paper, we analyse the use of PlanetLab Europe for development and evaluation of geographically-oriented Internet services. PlanetLab is a global research network with the main purpose to support development of new Internet services and protocols.
Dan Komosny   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

An Empirical Investigation of Geographically Distributed Agile Development: The Agile Enterprise Architecture is a Communication Enabler

open access: yesIEEE Access, 2020
Agile software development performance depends on active communication. Active communication is an arduous task when agile teams are geographically distributed.
Yehia Ibrahim Alzoubi, Asif Qumer Gill
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

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