Results 41 to 50 of about 776,037 (264)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Software Update Methodologies for Feature-Based Product Lines: A Combined Design Approach

Software
The automotive industry is experiencing a significant shift, transitioning from traditional hardware-centric systems to more advanced software-defined architectures. This change is enabling enhanced autonomy, connectivity, safety, and improved in-vehicle
Abir Bazzi, Adnan Shaout, Di Ma
doaj   +1 more source

Development of Distributed Automotive Software [PDF]

, 2006
The software complexity in modern vehicle electronic systems is increasingly growing. Vehicle projects have to take into account a growing number of interconnected functions, which are jointly developed by many persons in many different companies. For facing these challenges, new design methodologies for a formalized and partially automated software ...
Uwe Honekamp, Matthias Wernicke
openaire   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

THE CHOICE OF TECHNOLOGICAL SOLUTIONS FOR SOFTWARE DEVELOPMENT FOR DISTRIBUTED INFORMATION SYSTEMS

Современные информационные технологии и IT-образование, 2018
The choice of tools and programming technologies for creating information systems is a current trend. Each projected system needs you to define a set of criteria for the development environment used by li- braries and technologies. This article considers
Dmitry Yu. Ilyin, Evgeny V. Nikulchev, Pavel V. Kolyasnikov   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Decision Support System for Risk Assessment and Management Strategies in Distributed Software Development

IEEE Access, 2017
Risk management in distributed software development (DSD) is a well-researched area, providing different methods for assessing risks and suggesting control strategies.
Adeel Aslam, Naveed Ahmad, Tanzila Saba, Abdulaziz S. Almazyad, Amjad Rehman, Adeel Anjum, Abid Khan   +6 more
doaj   +1 more source

MANAGEMENT SYSTEM FOR SCALABLE GEOGRAPHICALLY DISTRIBUTED DATA CENTER [PDF]

Научно-технический вестник информационных технологий, механики и оптики, 2019
Subject of Research. The paper presents results of the management system development for a scalable geographically distributed data center. Special attention is paid to system versatility in view of new tasks, resource efficiency, operational reliability
Sergey E. Khoruzhnikov, Andrey Ye. Shevel   +1 more
doaj   +1 more source