Results 51 to 60 of about 776,037 (264)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Enabling End-to-End Orchestration of Multi-Cloud Applications

IEEE Access, 2017
The orchestration of application components across heterogeneous cloud providers is a problem that has been tackled using various approaches, some of which led to the creation of cloud orchestration and management standards, such as TOSCA and CAMP ...
Kena Alexander, Choonhwa Lee, Eunsam Kim, Sumi Helal   +3 more
doaj   +1 more source

Better together: Elements of successful scientific software development in a distributed collaborative community.

PLoS Computational Biology, 2020
Many scientific disciplines rely on computational methods for data analysis, model generation, and prediction. Implementing these methods is often accomplished by researchers with domain expertise but without formal training in software engineering or ...
Julia Koehler Leman, Brian D Weitzner, P Douglas Renfrew, Steven M Lewis, Rocco Moretti, Andrew M Watkins, Vikram Khipple Mulligan, Sergey Lyskov, Jared Adolf-Bryfogle, Jason W Labonte, Justyna Krys, RosettaCommons Consortium, Christopher Bystroff, William Schief, Dominik Gront, Ora Schueler-Furman, David Baker, Philip Bradley, Roland Dunbrack, Tanja Kortemme, Andrew Leaver-Fay, Charlie E M Strauss, Jens Meiler, Brian Kuhlman, Jeffrey J Gray, Richard Bonneau   +25 more
doaj   +1 more source

A flexible framework for requirement management (FFRM) from software architecture toward distributed agile framework

Open Computer Science, 2022
GSD is a Global software development environment where data are distributed to more than two sites. These sites may be located on national or continental borders.
Nadeem Rao, Amir Latif Rana M., Hussain Khalid, Jhanjhi N. Z., Humayun Mamoona   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Assessing the Determinants of Adopting Component-Based Development in a Global Context: A Client-Vendor Analysis

IEEE Access, 2018
Component-based software (CBS) development is an attractive proposition to globally distributed software development organizations because of its potential to integrate reusable components in new products.
Muhammad Jalal Khan, Sajjad Mahmood
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Interaction Design in Distributed Software Development: What we know and what we don’t know

Journal on Interactive Systems
Human-Computer Interaction (HCI) is an area focused on human interaction with/through computational systems, among which tangent studies on interaction design stand out.
Daniel Domingos Alves, Ecivaldo de Souza Matos   +1 more
doaj   +1 more source

Dynamic Agile Distributed Development Method

Mathematics, 2019
“Agile” is an effective software engineering model with a high trust and acceptance rate among its users. The term agility comes from the concept of rapid development and working in a team for better results and a faster competition rate when
Muhammad Asgher Nadeem, Scott Uk-Jin Lee   +1 more
doaj   +1 more source

Towards Taxonomical-Based Situational Model to Improve the Quality of Agile Distributed Teams

IEEE Access, 2020
At present, software organizations are developing software products that employ global software development (GSD) teams. Organizations tend to adopt new methodologies for global software development, among which is the use of agile in the GSD industry ...
Amber Sarwar, Yaser Hafeez, Shariq Hussain, Shunkun Yang   +3 more
doaj   +1 more source