Results 91 to 100 of about 1,166,515 (289)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

A Novel Control Strategy on Multiple-Mode Application of Electric Vehicle in Distributed Photovoltaic Systems

open access: yesComplexity, 2018
Considering the booming development of electric vehicle (EV), this article presents a novel control scheme analyzing EV multiple-mode application in a number of distributed photovoltaic (PV) systems, which rationalizes the energy flow among the energy ...
Qianwen Zhong, Yize Sun, Lele Peng
doaj   +1 more source

Data on reducing carbon footprint in microgrids using distributed battery energy storage

open access: yesData in Brief, 2019
This data presented in this article was collected using simulations on a microgrid system to analyze reduction of carbon footprints using distributed battery storage devices.
Javad Khazaei, Colton Schlauderaff
doaj   +1 more source

Performance evaluation of the Mojette erasure code for fault-tolerant distributed hot data storage [PDF]

open access: yes, 2015
Packet erasure codes are today a real alternative to replication in fault tolerant distributed storage systems. In this paper, we propose the Mojette erasure code based on the Mojette transform, a formerly tomographic tool.
Féron, Didier   +3 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

NSSDC Conference on Mass Storage Systems and Technologies for Space and Earth Science Applications, volume 1 [PDF]

open access: yes
Papers and viewgraphs from the conference are presented. This conference served as a broad forum for the discussion of a number of important issues in the field of mass storage systems.
Blasso, L. G.   +2 more
core   +1 more source

Home - About - Disclaimer - Privacy