Results 131 to 140 of about 11,258,293 (306)
Information theory inspired optimization algorithm for efficient service orchestration in distributed systems. [PDF]
PLoS One, 2021 Lima MS.
europepmc +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Big Data and Cognitive ComputingArtificial Intelligence is increasingly used to support decision-making across many domains. However, concerns related to transparency, reliability and human oversight indicate the need for improved human-centered AI (HCAI) approaches in decision support
Marco Fanfani +2 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Distributed Cognition in the Age of Distributed Systems.
, 2015 In parallel with the development of the theory of distributed cognition, the study of distributed computing has progressed rapidly. This research has both been driven by pragmatic insights into the practicalities of coordinating computational processes and resulted in formal theories of distributed systems.
Soutar-Rau, Ethan, Fisher, Brian
openaire +2 more sources
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Automated testing of distributed systems using on-demand virtual infrastructure [PDF]
, 2013 Distributed systems comprise distributed computing systems, distributed information systems, and distributed pervasive systems. They are often very complex and their implementation is challenging.
Kroll, Phillip
core
Coordinating Open Distributed Systems
, 1999 Open Distributed Systems are the dominating intellectual issue of the end of this century. Figuring out how to build those systems will become a central issue in distributed system research in the next future.
Ducasse, Stephane, Cruz, Juan-Carlos
core +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source