Results 31 to 40 of about 495,712 (260)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Applied SciencesThis paper presents a unified technical survey of Large Language Models (LLMs), connecting three layers of the modelling pipeline that existing surveys address in isolation: internal architecture, distributed training optimisation, and downstream ...
Martin Lukáč +8 more
doaj +1 more source
Distributed Online Course for Educator Training
Высшее образование в России, 2020 The general digitalization of contemporary society leads to a change in the use of learning technology in engineering education. The aim of this article is to present the advantages of the corporate online course for faculty members’ advanced training ...
V. A. Starodubtsev, I. V. Ryashentsev
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A study of pipeline parallelism in deep neural networks
Revista Colombiana de ComputaciónThe current popularity in the application of artificial intelligence to solve complex problems is growing. The appearance of chats based on artificial intelligence or natural language processing has generated the creation of increasingly large and ...
Gabriel Núñez +3 more
doaj +5 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A university’s response to people with disabilities in Worcester, Western Cape
African Journal of Disability, 2019 Background: The call for institutions of higher education to foster interaction with communities and ensure training is responsive to the needs of communities is well documented.
Jana V. Müller +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source