Results 91 to 100 of about 4,316,593 (300)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Efficient content-distribution in a hybrid opportunistic network [PDF]

, 2011
Information or content centric networking is believed by many to have great potential to be the appropriate networking paradigm for the future Internet.
Lindgren, Anders
core   +1 more source

Scale-free trees: the skeletons of complex networks

, 2004
We investigate the properties of the spanning trees of various real-world and model networks. The spanning tree representing the communication kernel of the original network is determined by maximizing total weight of edges, whose weights are given by ...
Dong-Hee Kim, H. Jeong, Hawoong Jeong, Jae Dong Noh, P. Erdös   +4 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Bayesian Policy Gradients via Alpha Divergence Dropout Inference

, 2011
Policy gradient methods have had great success in solving continuous control tasks, yet the stochastic nature of such problems makes deterministic value estimation difficult.
Henderson, Peter, Doan, Thang, Islam, Riashat, Meger, David   +3 more
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Synchronization-Desynchronization Transitions in Complex Networks: An Interplay of Distributed Time Delay and Inhibitory Nodes

, 2014
We investigate the combined effects of distributed delay and the balance between excitatory and inhibitory nodes on the stability of synchronous oscillations in a network of coupled Stuart--Landau oscillators.
Lehnert, Judith, Schöll, Eckehard, Wille, Carolin   +2 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A Novel Feature Engineering-Based SOH Estimation Method for Lithium-Ion Battery with Downgraded Laboratory Data

Batteries
Accurate estimation of lithium-ion battery state of health (SOH) can effectively improve the operational safety of electric vehicles and optimize the battery operation strategy.
Jinyu Wang, Caiping Zhang, Xiangfeng Meng, Linjing Zhang, Xu Li, Weige Zhang   +5 more
doaj   +1 more source

State-of-Charge Balancing Control of a Modular Multilevel Converter with an Integrated Battery Energy Storage

Energies, 2018
With the fast development of the electric vehicle industry, the reuse of second-life batteries in vehicles are becoming more attractive, however, both the state-of-charge (SOC) inconsistency and the capacity inconsistency of second-life batteries have ...
Hui Liang, Long Guo, Junhong Song, Yong Yang, Weige Zhang, Hongfeng Qi   +5 more
doaj   +1 more source