Results 81 to 90 of about 9,782,796 (306)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
BatteriesAccurate estimation of lithium-ion battery state of health (SOH) can effectively improve the operational safety of electric vehicles and optimize the battery operation strategy.
Jinyu Wang +5 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Mixed Cumulative Distribution Networks
CoRR, 2010 11 pages, 4 ...
Silva, R, Blundell, C, Teh, Y
openaire +4 more sources
Energies, 2018 With the fast development of the electric vehicle industry, the reuse of second-life batteries in vehicles are becoming more attractive, however, both the state-of-charge (SOC) inconsistency and the capacity inconsistency of second-life batteries have ...
Hui Liang +5 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Distributed Corruption Detection in Networks
Theory Comput., 2015 We consider the problem of distributed corruption detection in networks. In this model, each vertex of a directed graph is either truthful or corrupt. Each vertex reports the type (truthful or corrupt) of each of its outneighbors. If it is truthful, it reports the truth, whereas if it is corrupt, it reports adversarially.
Alon, N, Mossel, E, Pemantle, R
openaire +5 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Greening elements in the distribution networks
Journal of Industrial Engineering and Management, 2010 Due to climate change and the increase in environmental awareness in the world, the concept of Green Supply Chain Management appeared. The concept is aimed at the reduction of several elements: energy, materials, the pollution and the waste in production and logistics processes. Power networks are a part of a supply chain of production and distribution
Opetuk, Tihomir +2 more
openaire +8 more sources