Results 91 to 100 of about 166,083,503 (302)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
SMARANDACHE SEQUENCE OF HAPPY NUMBERS [PDF]
, 2003 In this article, we present the resuhs of investigation of Smarandache Concatenate Sequence formed from the sequence of Happy Numbers and report some primes and other results found from the ...
Gupta, Shyam Sunder
core +1 more source
Equations for a potential algebraic approach to the twin prime conjecture. Addendum to: "On the numbers that determine the distribution of twin primes" [PDF]
Surveys in Mathematics and its ApplicationsThis is an Addendum to: Article: On the numbers that determine the distribution of twin primes Author: Antonie Dinculescu Published in: Surveys in Mathematics and its Applications, 13 (2018), 171–181. Full text:
Antonie Dinculescu
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
, 2011 Knowledge about number theory and prime numbersEuclid proved that the number of prime numbers is infinite. Prime numbers seem to be arranged in an unpredictable way, but sometimes patterns emerge.
Zenil, Hector
core +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Large sieve inequalities for exceptional Maass forms and the greatest prime factor of $n^2+1$
Forum of Mathematics, PiWe prove new large sieve inequalities for the Fourier coefficients $\rho _{j\mathfrak {a}}(n)$ of exceptional Maass forms of a given level, weighted by sequences $(a_n)$ with sparse Fourier transforms – including two key types of sequences ...
Alexandru Pascadi
doaj +1 more source
On a Dynamical Approach to Some Prime Number Sequences
Entropy, 2018 We show how the cross-disciplinary transfer of techniques from dynamical systems theory to number theory can be a fruitful avenue for research. We illustrate this idea by exploring from a nonlinear and symbolic dynamics viewpoint certain patterns ...
Lucas Lacasa +3 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Variants on Andrica’s Conjecture with and without the Riemann Hypothesis
Mathematics, 2018 The gap between what we can explicitly prove regarding the distribution of primes and what we suspect regarding the distribution of primes is enormous. It is (reasonably) well-known that the Riemann hypothesis is not sufficient to prove Andrica’s ...
Matt Visser
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