Results 71 to 80 of about 642,937 (309)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Concession model for fair distribution of benefits and risks in build-operate-transfer road projects

Journal of Civil Engineering and Management, 2019
A fair distribution of benefits and risks is not only one of the key factors in deciding concession period but also an important prerequisite for good cooperation between the government and the private sector in a Build-Operate-Transfer (BOT) road ...
Xue Yan, Heap-Yih Chong, Jing Zhou, Qian Li   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Quantifying Uncertainties in Global Growth Forecasts

, 2016
This paper presents a procedure to construct an asymmetric fan chart of risks around global growth forecasts. The distribution of risks around global growth forecasts is estimated by weighting information
Ohnsorge, Franziska L., Stocker, Marc, Some, Modeste Y.   +2 more
core   +2 more sources

Some bioethical challenges of the health system in the COVID-19 pandemic [PDF]

, 2020
The COVID-19 pandemic revealed the existence of ethical and bioethical dilemmas related to the public health system and society and demonstrated that public health policies must be constantly analyzed and modified to rationalize medical resources, to ...
Rubanovici, Ludmila, Rusnac, Daniela
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Risk Management Systems for Contingent Infrastructure Liabilities : Applications to Improve Contract Design and Monitoring

, 1998
Government guarantees for private infrastructure projects represent real liabilities, and their costs can average as much as a third of the amount guaranteed. The authors show how governments can use a risk
Mody, Ashoka, Lewis, Christopher M.
core   +1 more source

Presupuestos para el reconocimiento de la mayor permanencia en el contrato de obra pública : aspectos doctrinales y jurisprudenciales

, 2021
Este estudio pretende identificar los presupuestos para que proceda el reconocimiento de la mayor permanencia en el contrato de obra pública, desde el análisis de su tipología contractual, daño o sobrecostos, imputación y distribución de riesgos; hasta ...
Neira Gaitán, Hans Leonardo
core   +2 more sources