Results 81 to 90 of about 642,937 (309)

Distribution, seasonal characteristics, ecological risks and human health risks of 9 antibiotics in the main water environment of Anhui province, China

Frontiers in Environmental Science
This study was performed to determine the status and ecological risk as well as provide a basis for the prevention and control of antibiotic contamination in the drinking water sources of Anhui Province.
Jie Tang, Yalin Han, Yan Zha, Xuede Li
doaj   +1 more source

The impact of distribution on value-at-risk measures

Mathematical and Computer Modelling, 2013
Abstract Value at risk is a popular approach to aid financial risk management. Questions about the appropriateness of the measure have arisen since the related 2008 bubble collapses in some US housing markets and the global financial market. These questions include the presence of fat tails and their impact.
David L. Olson, Desheng Wu
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Il geometra e i vulnerabili. Sugli usi del concetto di vulnerabilità nelle scienze sociali

, 2016
Nowadays the concept of "vulnerability" covers a vertiginously widening semantic field. The paper aims at clarifying the meaning of the concept in social sciences.
Lucia Re, GIOLO, Orsetta
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

STRATEGIC RISKS IN INDUSTRY 4.0 – SCALABILITY PERSPECTIVE

Humanities and Social Sciences
This article identifies key strategic risks relating to the functioning of organizations within Industry 4.0, emphasizing scalability. It employs a quantitative CAWI survey that involves 400 organizations from 16 European countries.
Rafal TRZASKA, Aleksandra SUS, Maciej WILCZYŃSKI, Agnieszka BEKISZ   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

[spatial Distribution Of Risks For Work-related Injuries In A City Of Southeastern Brazil].

, 2015
To assess spatial distribution of risks for work-related injuries controlled for nutritional variables and other covariables. Hospital-based spatial case-control study with work-related injuries spatial distribution as the main variable of interest.
Medeiros, Maria Angélica Tavares de, Zangirolani, Lia Thieme Oikawa, Stephan, Celso, Cordeiro, Ricardo   +3 more
core  

Evaluation of Economic Risk of Construction Order from Perspective of Supplier

, 2015
This thesis deals with the evaluation of economic risk at a construction point of view of the contractor. The thesis described distribution of risks,identification and risk assessment.The practical part describes and evaluates financial risks specific ...
Durecová, Martina
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source