Results 151 to 160 of about 3,209,718 (264)

A new class of Lindley distribution: System reliability, simulation and applications. [PDF]

Heliyon
Qayoom D, Rather AA, Alsadat N, Hussam E, Gemeay AM.   +4 more
europepmc   +1 more source

Use of a novel pressure distribution system for severely ill neonates: a clinical pilot study carried out by the PREPICare consortium. [PDF]

BMC Pediatr, 2023
Schlüer AB, Müller AY, Fromme NP, Camenzind M, Riener R, Rossi RM, Aufdenblatten BB.   +6 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Quantitative microbial risk assessment of <i>Legionella pneumophila</i> in a drinking water distribution system: A case study. [PDF]

New Microbes New Infect
Ranjdoost SM, Owrang M.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Biofilm detachment significantly affects biological stability of drinking water during intermittent water supply in a pilot scale water distribution system. [PDF]

Sci Rep
Leifels M, Cheng D, Cai J, Nadhirah N, Mohidin AF, Santillan E, Woo Y, Hill E, Wu SW, Boon N, Favere J, Whittle AJ, Wuertz S.   +12 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Household-Level Variability of Nontarget Analytical Results for Drinking Water Provides a Tool for Uncovering Constituents Introduced by Distribution System Components. [PDF]

Environ Sci Technol
Black GP, Young TM.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Public sector pharmaceutical distribution system and its challenges: a case of a central Ethiopian Pharmaceuticals Supply Service and selected branches. [PDF]

BMC Health Serv Res
Getahun KT, Bilal AI, Cho DJ.
europepmc   +1 more source