Results 141 to 150 of about 2,335,988 (318)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Reliability Evaluation of Distribution Systems

Reliability of the electric power supply is essential in modern society. The electric power system with its generation, as well as its transmission and distribution networks, is one of the most complex technical systems that humanity has created ...
Zemīte, Laila, Gerhards, Jānis
core  

Optimisation of pump operations in water distribution systems taking into account the seasonality of the demand

, 2012
Although the optimisation of pump operations in water distribution systems has previously been researched considering different types of pumps and controls, the variation of the water demand throughout the year and its impact on pumping have never been ...
Sutanto, S., Do, N.C., Thyer, M.A., Simpson, A.R., Marchi, A.   +4 more
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Scenarios of Contaminant Diffusion on a Medium Size Urban Water Distribution Network

, 2009
Heightened concern over potential acts of sabotage against water distribution systems is imparting greater importance to the conceptualization of contaminant migration and the value of simulating contaminant dispersion scenarios which are as realistic as
O. Giustolisi, F. Primativo, A. Carbonara, A. Doglioni   +3 more
core   +1 more source

Fast and Scalable Three-Phase Voltage Sensitivity Method for Unbalanced Distribution Networks

IEEE Access
Voltage control in modern distribution systems (DSs) has been increasingly challenged by the high penetration of distributed energy resources (DERs), unbalanced three-phase topologies, and voltage-sensitive loads.
Cristhian R. da de Oliveira, Wandry R. Faria, Benvindo R. Pereira, Joao B. A. London   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A review of protection systems for distribution networks embedded with renewable generation

, 2016
The rapid growth of grid-connected embedded generation is changing the operational characteristics of power distribution networks. Amongst a range of issues being reported in the research, the effect of these changes on so-called 'traditional protection ...
Ciufo, Phil, Kennedy, Joel, Agalgaonkar, Ashish   +2 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source