Results 151 to 160 of about 2,335,988 (318)
, 1994 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis explores the architectural requirements of engineering design support systems based on knowledge based systems technology.
McDonnell, Janet Theresa
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Coping with uncertainty in the reliability evaluation of water distribution systems
, 2008 The application of the reliability analysis techniques to the water distribution systems aims to properly achieve in probabilistic terms the fulfilment of the nodal demand in a conceptual and physical context subject to different causes of uncertainties.
G. DARVINI +5 more
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Modelling water quality for water distribution systems
, 1999 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Maintaining water quality in distribution systems has become a prominent issue in the study of water networks.
Maier, Stefan Heinrich
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
, 2012 The primary purpose of this study was to identify common characteristics associated with the distribution center performance-leveraging activities. The second objective was to examine empirically the impact of information systems on the performance of ...
Yang, Li-Ren; Chen, Jieh-Haur
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Optimal distributed generation placement in radial distribution systems [PDF]
, 2012 Distributed generation (DG) resources are commonly used in the electric systems to obtain minimum line losses, as one of the benefits of DG, in radial distribution systems.
Yavartalab, A. +3 more
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