Results 61 to 70 of about 245,521 (278)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Configurations, Power Topologies and Applications of Hybrid Distribution Transformers

Energies, 2021
Distribution systems are under constant stress due to their highly variable operating conditions, which jeopardize distribution transformers and lines, degrading the end-user service.
Alvaro Carreno, Marcelo Perez, Carlos Baier, Alex Huang, Sanjay Rajendran, Mariusz Malinowski   +5 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Optimal passive filter design for effective utilization of cables and transformers under non-sinusoidal conditions [PDF]

, 2014
Transformers and cables have overheating and reduced loading capabilities under non-sinusoidal conditions due to the fact that their losses increases with not only rms value but also frequency of the load current.
Aleem, SHEA, Balci, ME, Sakar, S, Zobaa, AF   +3 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Space Charge Accumulation under Effects of Temperature Gradient and Applied Voltage Reversal on Solid Dielectric DC Cable [PDF]

, 2009
A well-known fact of the existence and accumulation of space charge within the insulating material poses threat to the reliability in the operation of dc power cables.
Chen, George, Choo, Wilson, Swingler, Steve   +2 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Efficient Strategy for Distribution Transformer Replacement: A Study on Replacement Methods in Power Systems

Jurnal ELTIKOM: Jurnal Teknik Elektro, Teknologi Informasi dan Komputer
A dependable and efficient electric power distribution system is increasingly required due to growing industrial and population demand. Many distribution transformers currently in use are outdated, which increases operating expenses and reduces ...
Nur Asmi Rahmawati
doaj   +1 more source

Distribution transformer cluster flexible dispatching method based on discrete monkey algorithm

Energy Reports, 2021
Distributed generators are being widely integrated into China’s urban distribution network unevenly, which accounts for different load rates of distribution transformer cluster in spatial dimension and low net load simultaneity rate in temporal dimension.
Bing Sun, Yunfei Li, Yuan Zeng, Chen Li, Jidong Shi, Xiaobo Ma   +5 more
doaj   +1 more source