Results 71 to 80 of about 4,658,734 (302)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Electromagnetic Time-Reversal Fault Location Using Active Pulse Injection

Applied Sciences
Existing EMTR methods typically adopt passive location schemes that rely on transient signals generated by faults. When faults occur at a low inception angle, the resulting traveling-wave signals are typically weak and suffer from poor detectability ...
Yuchu Lu, Wei Dong, Chengxuan Tang, Yuewei Tian, Xun Huang, Yueheng Meng, Yongxiang Cai, Youzhuo Zheng, Haonan Cui, Niancheng Zhou   +9 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Comprehensive Condition Evaluation of Distribution Transformer Considering Internal Operation, External Environment, and Load Operation for Business Expansion

Energies
This paper proposes a comprehensive condition evaluation method for distribution transformers considering their internal operation, external environment, and load operation for business expansion.
Shengxiang Xie, Danni Dai, Weifeng Dong, Yuling He   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Power quality improvement using dynamic voltage restorer in electrical distribution system: an overview [PDF]

, 2020
This paper represents a review of the dynamic voltage restorer for power quality improvement in the electrical distribution system. Over the past 50 years, issues concerning power quality have steadily increased, to prevent the effect of the voltage ...
Ali Basim Mohammed, Sofia Najwa Ramli, Mohammed, Ali Basim, Ramli, Sofia Najwa, Mohd Aifaa Mohd Ariff, Najwa Ramli, Sofia, Mohd Ariff, Mohd Aifaa   +6 more
core   +1 more source

DISTRIBUTION TRANSFORMER MONITORING SYSTEM [PDF]

, 2021
A transformer is very important in substation and power system. The data assets and provision of transformer is an very important aspect in electric network as huge number distribution transformers are distributed a huge area.
BASAVARAJ C. BIRAJDAR, BAJIRAO S. PATIL, SAHIL P. JADHAV   +2 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Lightening-Transformer-AE

, 2023
Artifact evaluation for HPCA'24 paper Lightening-Transformer: A Dynamically-operated Optically-interconnected Photonic Transformer ...
Hanqing Zhu (17448903)
core   +1 more source