Results 101 to 110 of about 2,000,911 (262)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Heavy-tailed distributions in VaR calculations [PDF]
The essence of the Value-at-Risk (VaR) and Expected Shortfall (ES) computations is estimation of low quantiles in the portfolio return distributions.
Rafal Weron, Adam Misiorek
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Comparisons of Heterogeneous Distributions and Dominance Criteria [PDF]
We are interested in the comparisons of standard-of-living across societies when observations of both income and household structure are available. We generalise the approach of Atkinson and Bourguignon (1987) to the case where the marginal distributions
Patrick MOYES (GREThA et IDEP Marseille)
core
Analytical properties of generalized Gaussian distributions
, 2018 Journal of Statistical Distributions and Applications 2018 5:
Shamai, Shlomo +4 more
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
HE 2.1.2 HADRON DISTRIBUTIONS IN THE CORE OF 100 TeV EXTENSIVE AIR SHOWERS
, 2007 With the central hadron calorimeter of the KASCADE experiment the cores of extensive air showers corresponding to primary energies around 100 TeV are investigated. The accurate position of the shower core is determined with a scintillator array on top of
Hadron Distributions In, J. Unger
core
Universal Approximation and the Topological Neural Network
IEEE AccessA topological neural network (TNN), which takes input data from a Tychonoff topological space instead of the usual finite dimensional space, is introduced.
Michael A. Kouritzin, Daniel Richard
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source