Results 121 to 130 of about 2,246,072 (312)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Report of the Chief Engineer of the Fire Department of the District of Columbia, 1924
, 1924 Report by the Chief Engineer of the Fire Department to the Board of Commissioners of the District of Columbia for the fiscal year ending June 30 ...
District of Columbia. Fire Departmentet al
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Twelfth annual report of the Department of Playgrounds of the District of Columbia, 1923
, 1923 Report of the Department of Playgrounds to the Board of Commissioners of the District of Columbia for the fiscal year ending June 30 ...
District of Columbia. Department of Playgroundset al
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Annual report of Director of Traffic of District of the Columbia, 1927
, 1927 Report of the Director of Traffic to the Board of Commissioners of the District of Columbia for the fiscal year ending June 30 ...
District of Columbia. Director of Trafficet al
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Report of the Operations of the Engineer Department of the District of Columbia, 1926
, 1926 Extract from the Report by the Board of Commissioners of the District of Columbia to Congress about government operations for the fiscal year ending June 30 ...
District of Columbia. Engineer Departmentet al
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Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Astoria District annual report
, 2005 This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.2005-Mode of access: Internet from the Oregon Government ...
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