Results 131 to 140 of about 2,246,072 (312)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Annual reports of Board of Trustees and Librarian of Public Library of the District of Columbia, 1926

, 1926
Report of the Board of Trustees of the District of Columbia, and the Librarian of the District of Columbia to the Board of Commissioners of the District of Columbia, during the fiscal year ending June 30, 1926.
District of Columbia. Public Library.et al
core  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Annual report of the Board of Commissioners of the District of Columbia, volume 5, 1917

, 1917
Volume five of the report of the Board of Commissioners of the District of Columbia to Congress about government operations for the fiscal year ending June 30, 1917.
District of Columbia. Board of Commissioners District of Columbia. Department of Insuranceet al
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Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Annual report of the Board of Commissioners of the District of Columbia, volume 4, 1918

, 1917
Volume four of the report of the Board of Commissioners of the District of Columbia to Congress about government operations for the fiscal year ending June 30, 1918. Volume includes the Report of the Board of Education.
District of Columbia. Board of Commissioners District of Columbia. Board of Educationet al, District of Columbia. Board of Commissioners District of Columbia. Department of Insuranceet al, District of Columbia. Board of Commissioners District of Columbia. Board of Healthet al   +2 more
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ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Report of the Board of Commissioners of the District of Columbia, 1874

, 1874
Report of the Board of Commissioners of the District of Columbia to the President of the United States about government operations for the fiscal year ending June 30, 1875, which includes reports of the Board of Audit and the Board of ...
District of Columbia. Board of Commissioners District of Columbia. Office of the Auditor; District of Columbia. Board of Healthet al
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Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Report of the Board of Commissioners of the District of Columbia, volume 4, 1902

, 1902
Volume 4 of the report of the Board of Commissioners of the District of Columbia to the President of the United States about government operations for the fiscal year ending June 30, 1902.
District of Columbia. Board of Commissioners District of Columbia. Board of Educationet al
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