Results 31 to 40 of about 736,343 (218)
Challenges of Decentralization of Primary Education in Bukedea District in Uganda
Interdisciplinary Journal of Education, 2019 The study was about decentralization challenges in Government Aided Primary Schools in Bukedea District. The objectives were; to identify the challenges of decentralized supervision practices and assess the challenges of decentralized financial ...
Alphonse Horrai Alumu, Amina Hassan
doaj +1 more source
The Baltics and Russian North-West: the Core and the Periphery in the 2000s [PDF]
Baltic Region, 2014 This article analyses population changes in North-West regions of Russia (the former North-Western economic zone and the Kaliningrad region) and the Baltics at the level of urban districts and municipalities.
Mkrtchyan N., Karachurina L.
doaj +1 more source
Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma
Pediatric Blood &Cancer, EarlyView.ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul +13 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Families of children with cancer experience significant financial strain, even with universal healthcare. Indirect costs, such as productivity losses and non‐medical expenses, are rarely included in economic evaluations, and little is known about how effectively financial aid programmes alleviate this burden. Childhood brain tumours
Megumi Lim +8 more
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Estudios Geográficos, 2015 La ciencia, la tecnología, la innovación y el emprendimiento son medios prioritarios para el desarrollo económico de Colombia, que sustentan y potencian recursos y capacidades locales.
Carlos Mario Molina Betancur +1 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Nearly Net-Zero Exergy Districts as Models for Smart Energy Systems
Journal of Sustainable Development of Energy, Water and Environment Systems, 2017 The planning of urban settlements requires a targeted approach towards more sustainable energy, water, and environment systems. This research work analyses the city of Uppsala and a district that is an urban renewal project at the site of former high ...
Şiir Kilkiş
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source