Results 41 to 50 of about 750,589 (262)
The concept of agroecosystem services combines environmental and socio-economic approaches to the analysis and evaluation of natural capital. A multi-criteria approach to spatial quantification of ecosystem services allows explicit assessment of the ...
Jarmila Makovníková +4 more
doaj +1 more source
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm +11 more
wiley +1 more source
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi +5 more
wiley +1 more source
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye +33 more
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Pékin tourne le dos à ses rues ?
L’article propose une interprétation des formes urbaines à Pékin en insistant sur le degré d’ouverture ou de fermeture des îlots. Il prend pour postulat que les évolutions urbaines de Pékin s’inscrivent dans une certaine continuité dans la conception des
David Bénazéraf
doaj +1 more source
Hybrid renewable energy systems are an optimal solution for small energy communities’ energy supply. One of the critical issues is the strong correlation of these systems with outdoor climatic conditions.
Nicoletta Matera +3 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
“Fruitières comtoises” (Franche-Comté, France)
The first traces of breeders associated for merging together their milks to make marketable cheese (cooked pressed cheese) appear in the late Middle Ages (13th century). This entrepreneurial model really started to spread in the seventeenth century.
Alain Mélo
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source

