Results 51 to 60 of about 691,837 (293)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Atypical symptoms and delayed diagnosis are more common in elderly patients with benign paroxysmal positional vertigo: a single-center study

Frontiers in Neurology
ObjectiveTo analyze the clinical characteristics of elderly patients with benign paroxysmal positional vertigo (BPPV), to provide a basis for the accurate diagnosis of elderly BPPV patients.MethodsA retrospective case-control study was conducted to ...
Hongyan Li, Hongyan Li, Yanping Tong, Yan Wang, Yan Wang, Meimei Chen, Meimei Chen, Yu Cui, Yu Cui, Xiaolin Wu, Xiaolin Wu, Yi Ju, Yi Ju   +12 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Flower reflectance and floral traits data from Ökologisch-Botanischer Garten (OBG), Germany

Data in Brief
Not all colours are perceived and interpreted equally. The electromagnetic spectrum is perceived differently by the distinct visual systems of animal species, resulting in differences in each species’ colour perception. Given the diverse colours found in
Mani Shrestha, Evelyn Hlawatsch, Hannah Pepe, Louis-Marvin Sander, Dietmar Schreier, Max Schuchardt, Andreas von Heßberg, Anke Jentsch   +7 more
doaj   +1 more source

Daily Maximum Temperatures Induce Lagged Effects on Leaf Unfolding in Temperate Woody Species Across Large Elevational Gradients

Frontiers in Plant Science, 2019
The timing of leaf unfolding in temperate woody species is predominantly controlled by the seasonal course of temperature in late winter and early spring. However, quantifying lagged temperature effects on spring phenology is still challenging.
Christof Bigler, Christof Bigler, Yann Vitasse, Yann Vitasse   +3 more
doaj   +1 more source

Coastal carbon processing rates increase with mangrove cover following a hurricane in Texas, USA

Ecosphere, 2022
Changes in species distributions and disturbances have complex impacts on ecosystem functioning. In many subtropical coastal wetlands, plant identity and cover are changing, as salt marshes dominated by low‐stature herbaceous species transition to woody ...
John S. Kominoski, Carolyn A. Weaver, Anna R. Armitage, Steven C. Pennings   +3 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Interaction Diversity Maintains Resiliency in a Frequently Disturbed Ecosystem

Frontiers in Ecology and Evolution, 2019
Frequently disturbed ecosystems are characterized by resilience to ecological disturbances. Longleaf pine ecosystems are not only resilient to frequent fire disturbance, but this feature sustains biodiversity.
Jane E. Dell, Jane E. Dell, Danielle M. Salcido, Will Lumpkin, Lora A. Richards, Scott M. Pokswinski, E. Louise Loudermilk, Joseph J. O'Brien, Lee A. Dyer   +8 more
doaj   +1 more source