Results 31 to 40 of about 725,179 (250)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Impacts of local human activities on the Antarctic environment [PDF]

, 2008
We review the scientific literature, especially from the past decade, on the impacts of human activities on the Antarctic environment. A range of impacts has been identified at a variety of spatial and temporal scales.
Agnew, Agnew, Ainley, Baker, Ballance, Bargagli, Barrera-Oro, Brown, C.A. Moreno, Chen, Clarke, Clarke, Constable, Constable, Constable, Convey, Convey, Convey, Convey, Cooney, Croxall, Croxall, D.G. Ainley, de Leeuw, de Poorter, Delord, DeVries, Duhamel, Edwards, Fraser, Frenot, Gon, Greenslade, Greenslade, Greenslade, Gremmen, Gröndahl, Hansom, Hee, Hemmings, Hofman, Holmes, Hughes, Huiskes, I. Snape, J. Scott, Jones, Jouventin, K.A. Hughes, Kennicutt, Kerry, Knox, Kock, Kock, Kock, Kohnen, Laws, McDonald, Moreno, Morris, Muller-Schwarze, Naveen, Naveen, Nicol, Ohtani, Olech, Otley, P. Convey, Pauly, Pauly, Peter, Pfeiffer, Pfeiffer, Rounsevell, S. Pfeiffer, Salwicka, Sjoling, Sladen, Smith, Smith, Snape, Snape, Summerson, T. Tin, Tejedo, Thor, Trathan, Weimerskirch, Wheeler, Willock, Woehler, Z.L. Fleming   +91 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A prospective analysis of sleep deprivation and disturbance in surgical patients [PDF]

, 2016
Introduction: Sleep deprivation has a potentially deleterious effect on postoperative recovery. The aim of our prospective study was to identify the factors contributing to postoperative sleep deprivation and disturbance in order to recommend ...
Camilleri-Brennan, John, Dolan, Ross, Huh, Jae, Sproat, Tom, Tiwari, Neil   +4 more
core   +3 more sources

Disturbed Landscape/Disturbing Processes: Environmental History for the Twenty-First Century

Pacific Historical Review, 2001
On the first weekend of May 2000, the opening act of the nation’s most impressive environmental drama of the summer was staged in Los Alamos, New Mexico. News releases covered a massive forest Ž re, named the Cerro Grande, exploding through forest stands, consuming over 40,000 acres of homes, recreation areas, and wildlands, burning perilously close to
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Omnipresence of Television and the Ascendancy of Surveillance/Sousveillance in Ray Bradbury's Fahrenheit 451 [PDF]

, 2017
This paper is an attempt to analyze Ray Bradbury's Fahrenheit 451(1953) under the light of Jean Baudrillard's notions on the media and the influences it exerts on people's daily lives, and with an eye to Michel Foucault's surveillance as well.
Abootalebi, H. (Hassan)
core