Results 41 to 50 of about 725,179 (250)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Faktor-faktor yang Berhubungan dengan Gangguan Fungsi Paru pada Pekerja di Unit Boiler Industri Tekstil X Kabupaten Semarang [PDF]

open access: yes, 2016
One of the negative impacts of boiler operation using coal fuel is air pollution caused by coal dust. Respirable coal dust can risk workers of lung function disturbance either restriction, obstruction or mixed.
Afiani, E. E. (Ellita)   +2 more
core  

Post-disturbance vegetation dynamics during the Late Pleistocene and the Holocene: An example from NW Iberia [PDF]

open access: yes, 2012
This is the post-print version of the final paper published in Global and Planetary Change. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural ...
Allen   +67 more
core   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Schizophrenia, social practices and cultural values: A conceptual introduction [PDF]

open access: yes, 2018
Schizophrenia is usually described as a fragmentation of subjective experience and the impossibility to engage in meaningful cultural and intersubjective practices. Although the term schizophrenia is less than 100 years old, madness is generally believed
Gonçalves, J.   +2 more
core   +1 more source

Disturbance History and Decline of American Chestnut [PDF]

open access: yes, 2017
Invasive diseases can interact with other disturbances and the environment to affect host population decline, realized niche, and interspecific interactions. In my dissertation, I sampled oak-chestnut forests first sampled for vegetation composition 66-89 years ago and conducted a field experiment to evaluate the effects of variance in environment, in ...
openaire   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Forest Stand Structure and Primary Production in relation to Ecosystem Development, Disturbance, and Canopy Composition [PDF]

open access: yes, 2016
Temperate forests are complex ecosystems that sequester carbon (C) in biomass. C storage is related to ecosystem-scale forest structure, changing over succession, disturbance, and with community composition.
Scheuermann, Cynthia M
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Aerodynamic instability: A case history [PDF]

open access: yes
The identification, diagnosis, and final correction of complex machinery malfunctions typically require the correlation of many parameters such as mechanical construction, process influence, maintenance history, and vibration response characteristics ...
Eisenmann, R. C.
core   +1 more source

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