Results 101 to 110 of about 1,312,330 (378)
Elucidation of the disulfide folding pathway of hirudin by a topology-based approach [PDF]
, 2003 A theoretical model for the folding of proteins containing disulfide bonds is introduced. The model exploits the knowledge of the native state to favour the progressive establishment of native interactions.
De Filippis, V. +3 more
core +2 more sources
Nano letters (Print), 2014 It is commonly observed that hydrophobic molecules alone cannot self-assemble into stable nanoparticles, requiring amphiphilic or ionic materials to support nanoparticle stability and function in vivo.
Yongjun Wang +15 more
semanticscholar +1 more source
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials, EarlyView.Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan +4 more
wiley +1 more source
Insights into the Role of the Unusual Disulfide Bond in Copper-Zinc Superoxide Dismutase*
Journal of Biological Chemistry, 2014 Background: Copper-zinc superoxide dismutase is a rare example of an intracellular protein with a disulfide bond. Results: Disulfide mutant C57S SOD1 has 10% of the enzymatic activity of wild type.
Kevin W. Sea +12 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.Heterojunctions combining halide perovskites with low‐dimensional materials enhance optoelectronic devices by enabling precise charge control and improving efficiency, stability, and speed. These synergies advance flexible electronics, wearable sensors, and neuromorphic computing, mimicking biological vision for real‐time image analysis and intelligent
Yu‐Jin Du +11 more
wiley +1 more source
iScience, 2021 Summary: The mammalian endoplasmic reticulum (ER) harbors more than 20 members of the protein disulfide isomerase (PDI) family that act to maintain proteostasis.
Chihiro Hirayama +7 more
doaj
PEGylation of native disulfide bonds in proteins [PDF]
Nature Protocols, 2006 PEGylation has turned proteins into important new biopharmaceuticals. The fundamental problems with the existing approaches to PEGylation are inefficient conjugation and the formation of heterogeneous mixtures. This is because poly(ethylene glycol) (PEG) is usually conjugated to nucleophilic amine residues. Our PEGylation protocol solves these problems
Ji-Won Choi +5 more
openaire +3 more sources
Journal of Biological Chemistry, 2014 Background: Peptide/protein hormones are stored as amyloids within endocrine secretory granules. Results: Disulfide bond cleavage enhances conformational dynamics and aggregation kinetics in somatostatin-14, resulting in amyloid fibrils with increased ...
Anoop Arunagiri +16 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.The temporary transition of macrophages from a pro‐inflammatory phenotype of macrophages (M1) to an anti‐inflammatory phenotype of macrophages (M2) is crucial for tissue repair and regeneration processes. Bacterial outer membrane vesicles (OMVs) are utilized as a “trojan horse” for specific M1 macrophage‐targeting and anti‐inflammatory drug delivery ...
Donglin Cai +9 more
wiley +1 more source
Synthesis and structural characterization of a mimetic membrane-anchored prion protein [PDF]
, 2006 During pathogenesis of transmissible spongiform encephalopathies (TSEs) an abnormal form (PrPSc) of the host encoded prion protein (PrPC) accumulates in insoluble fibrils and plaques. The two forms of PrP appear to have identical covalent structures, but
Andrew C. Gill +44 more
core +1 more source