Results 241 to 250 of about 96,012 (310)

Redox‐Programmed Activation of a Dual‐Modal Probe for High‐Fidelity Tumor Delineation and Image‐Guided Surgery

Advanced Science, EarlyView.
This study presents a glutathione (GSH)‐activatable dual‐modality probe (GAP9) with a redox‐tuned activation window for precise tumor detection. It remains quenched (“OFF”) in normal tissue yet activates specifically in tumors for T1‐weighted magnetic resonance imaging (MRI) preoperative mapping and near‐infrared II (NIR‐II) fluorescence intraoperative
Haohao Yan, Yanbin Feng, Qian Jia, Ruili Zhang, Zhongliang Wang   +4 more
wiley   +1 more source

Stapling Cysteine[2,4] Disulfide Bond of α-Conotoxin LsIA and Its Potential in Target Delivery. [PDF]

Mar Drugs
Sun X, Hu J, Ren M, Chang H, Zhangsun D, Zhang B, Dong S.   +6 more
europepmc   +1 more source

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, EarlyView.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source

Mechanism of Methylene Blue Inducing the Disulfide Bond Formation of Tubulin-Associated Unit Proteins. [PDF]

JACS Au
Seo DH, Huh YH, Cheong HK, Kim EH, Lim JS, Lee MJ, Lee D, Ryu KS.   +7 more
europepmc   +1 more source

Ultrafine Ru‐M Alloy@S Vacancy‐Rich MoS2 Nanosheets With Bimetallic Active Sites for Efficient Hydrogen Evolution in Alkaline and Acidic Media

Advanced Science, EarlyView.
A USMR synthesizes ultrafine RuCo alloy on S‐vacancy‐rich 1T phase MoS2. This method enables rapid precursor mixing, instantaneous reduction, and uniform alloy dispersion while creating S vacancies. The synergy between Ru‐Co sites and defective MoS2 optimizes hydrogen kinetics, achieving a low overpotential of 31 mV@10 mA·cm‐2 in acid, providing a ...
Rui Su, Tiantian Ding, Hao Tang, Xueying Yang, Jie Zhang, Xiaolin Liu, Jinfu Jia, Yuan Liu, Jin Ge, Zhilin Wu, Zhengya Dong, Xiaojing Zhu   +11 more
wiley   +1 more source

An extensive disulfide bond network prevents tail contraction in Agrobacterium tumefaciens phage Milano. [PDF]

Nat Commun
Sonani RR, Palmer LK, Esteves NC, Horton AA, Sebastian AL, Kelly RJ, Wang F, Kreutzberger MAB, Russell WK, Leiman PG, Scharf BE, Egelman EH.   +11 more
europepmc   +1 more source

Precision‐Engineered Silver Single‐Atom Carbon Dot Nanozymes for Theranostic Management of Acute Kidney Injury

Advanced Science, EarlyView.
Mitochondria‐targeted silver single‐atom carbon dot (T‐AgSA‐CDs) nanozymes enable dual SOD/GPx‐like ROS scavenging, real‐time imaging, and therapeutic effects for acute kidney injury (AKI). Atomically dispersed Ag sites synergize with carbon dots to restore renal redox hemostasis, protect mitochondrial function, mitigate inflammation, facilitate post ...
Tianle Tang, Jun Zhang, Yan Wang, Guoping Chen, Kehui Yuan, Yuan He, Chenchen Li, Sumaira Hanif, Yang Yang, Yanli Wang, Pir Muhammad   +10 more
wiley   +1 more source

The structure of Mycobacterium thermoresistibile MmpS5 reveals a conserved disulfide bond across mycobacteria. [PDF]

Metallomics
Cuthbert BJ, Mendoza J, de Miranda R, Papavinasasundaram K, Sassetti CM, Goulding CW.   +5 more
europepmc   +1 more source

Metal‐Organic Framework‐Based Supercapacitors: A Comprehensive Review

Advanced Science, EarlyView.
Overview of Metal‐Organic Frameworks (MOFs) derived electrode materials for supercapacitors. Illustration of redox reactions, conductivity enhancement, and structural stability during charge‐discharge cycling. Emphasis on synergistic effects due to surface area, porosity leading to improved electrochemical performance and energy storage efficiency ...
Swapnajit V. Mulik, Mrunal M. Patil, Sonali P. Sadavar, Sagar D. Delekar, Rajendra K. Bordia, Dillip K. Panda   +5 more
wiley   +1 more source

The interaction between NLRP1 and oxidized TRX1 involves a transient disulfide bond. [PDF]

Cell Chem Biol
Geeson MB, Hsiao JC, Tsamouri LP, Ball DP, Bachovchin DA.   +4 more
europepmc   +1 more source