Results 331 to 340 of about 1,312,330 (378)

Copper‐Based Nanotubes That Enhance Starvation Therapy Through Cuproptosis for Synergistic Cancer Treatment

Advanced Science, EarlyView.
We designed a copper‐based nanotube (NT) with copper ionophores to induce enhanced cuproptosis. In combination with starvation therapy, the NT significantly inhibited energy metabolism in HCC cells. Our results show that the depletion of GSH by Cu2+ intensified oxidative stress and cuproptosis, resulting in ROS generation and DLAT aggregation ...
Xuan Han, Xin Zhang, Zhiping Liu, Hang Liu, Derek Wu, Yinli He, Kexin Yuan, Yi Lyu, Xiaofei Liu   +8 more
wiley   +1 more source

A Salt Bridge and Disulfide Bond within the Lassa Virus Fusion Domain Are Required for the Initiation of Membrane Fusion. [PDF]

ACS Omega
Pennington HN, Birtles D, Shi ZW, Lee J.
europepmc   +1 more source

Cu‒S Covalent Bonds Enable the Anchoring of Single‐atom Cu on Layered MoS2 for Highly Selective and Active Photothermal Catalytic Conversion of CO2−H2O to Ethanol

Advanced Science, EarlyView.
Cu5%‐MoS2 with dual Cu and Mo active sites enables efficient photothermal synergistic catalysis of the CO2–H2O system for ethanol production. The catalyst achieves a high ethanol yield of 3.1 mmol·g−1·h−1 with 88.35% selectivity, showcasing exceptional performance and selectivity under mild conditions. Abstract The catalytic conversion of CO2 into high‐
Yingao Luo, Gaoli Chen, Zhongliao Wang, Sujuan Zhang, Xiuzhen Zheng, Sugang Meng, Shifu Chen   +6 more
wiley   +1 more source

Deciphering the Cofilin Oligomers via Intermolecular Disulfide Bond Formation: A Coarse-Grained Molecular Dynamics Approach to Understanding Cofilin's Regulation on Actin Filaments. [PDF]

J Phys Chem B
Li C, Wei TY, Cheung MS, Tsai MY.
europepmc   +1 more source

In Situ Electrically Resettable Field‐Effect Transistor Biosensors for Continuous and Multiplexed Neurotransmitter Detection

Advanced Science, EarlyView.
The research team integrated a potentiometrically controlled pH electrode with carbon nanotube (CNT) field‐effect transistor (FET) biosensors on a single chip using compatible processes. By employing zonal modification and optimized pH‐sensitive probes, they achieved simultaneous quadruple‐target detection and tenfold reusability under physiological ...
Bo Xiao, Tingxian Li, Xianmao Cao, Yang Zhang, Jianping He, Mengmeng Xiao, Zhiyong Zhang   +6 more
wiley   +1 more source

Deep Mutational Scanning Reveals a De Novo Disulfide Bond and Combinatorial Mutations for Engineering Thermostable Myoglobin

Küng C, Protsenko O, Vanella R, Nash MA.   +3 more
europepmc   +1 more source

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Disulfide bond formation in prokaryotes

Nature Microbiology, 2018
Interest in protein disulfide bond formation has recently increased because of the prominent role of disulfide bonds in bacterial virulence and survival. The first discovered pathway that introduces disulfide bonds into cell envelope proteins consists of Escherichia coli enzymes DsbA and DsbB.
Cristina Landeta, Jon Beckwith, Dana Boyd   +2 more
openaire   +3 more sources

Disulfide Bond Mimetics: Strategies and Challenges

Chemistry – A European Journal, 2017
AbstractThe activity profile of many biologically relevant proteins and peptides often relies on a precise 3D structural organization. In this context, disulfide bonds are natural covalent constraints that play a key role in driving and stabilizing the folding pattern of these molecules.
Gori A, Gagni P, Rinaldi S
openaire   +6 more sources

ChemInform Abstract: Disulfide Bond Formation in Peptides [PDF]

ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
George Barany, Lin Chen, Ioana Annis
openaire   +5 more sources