Results 51 to 60 of about 1,312,330 (378)

Disruption of reducing pathways is not essential for efficient disulfide bond formation in the cytoplasm of E. coli

Microbial Cell Factories, 2010
Background The formation of native disulfide bonds is a complex and essential post-translational modification for many proteins. The large scale production of these proteins can be difficult and depends on targeting the protein to a compartment in which ...
Hatahet Feras, Nguyen Van Dat, Salo Kirsi EH, Ruddock Lloyd W   +3 more
doaj   +1 more source

Research Progress on Disulfide Bond Assignment Analysis Based on Mass Spectrometry [PDF]

Zhipu Xuebao, 2021
Disulfide bond in protein is an important post translational modification and it is extremely essential for stabilizing the three dimensional structure of proteins, maintaining the correct folded conformation and regulating their biological activities ...
LI Ming, WU Pei-ze
doaj   +1 more source

The Interplay between Chemistry and Mechanics in the Transduction of a Mechanical Signal into a Biochemical Function [PDF]

, 2007
There are many processes in biology in which mechanical forces are generated. Force-bearing networks can transduce locally developed mechanical signals very extensively over different parts of the cell or tissues.
Ainavarapu, Alon, Altmann, Baker, Barakat, Barsegov, Becker, Bell, Best, Best, Bhasin, Braun, Brockwell, Brooks, Brooks, Bruno Samorì, Bryant, Bustamante, Bustanji, Bustanji, Cao, Carl, Carrion-Vazquez, Carson, Chang, Chtcheglova, Cieplak, Cluzel, De Keulenaer, De Los Rios, Dembo, Dettmann, Dietz, Discher, Doggett, Doggett, Dudko, Ericson, Evans, Evans, Evans, Evans, Evans, Evans, Fantner, Fantner, Fenouillet, Fernandez, Finger, Fisher, Fisher, Fowler, Francesco Valle, Fritz, Gao, Grandi, Guo, Heslot, Higgins, Hotchkiss, Hsiai, Hummer, Hyeon, Jackson, Jiang, Julien, Kawakami, Kellermayer, Kozuka, Kung, Lambert-Vidmar, Lawler, Lawrence, Lay, Lee, Lenne, Li, Li, Li, Li, Li, Li, Lincoln, Liphardt, Liphardt, Lou, Lou, Makarov, Marshall, Marszalek, Massimo Sandal, Matouschek, Matthias, Merkel, Mohamed, Morrow, Neupert, Oberhauser, Oberhauser, Pereverzev, Prajapati, Prakash, Qin, Rief, Rief, Rief, Rief, Ritort, Rouzina, Rubartelli, Rubenstein, Samori, Samori, Sandal, Sarasa-Renedo, Sarkar, Sato, Schnepel, Schulze, Schwaiger, Sengupta, Shimaoka, Smith, Smith, Smith, Smith, Stathakis, Stetefeld, Terada, Thirumalai, Thomas, Thomas, Thompson, Viani, Vladescu, Vogel, Vogel, Vologodskii, Waite, Welsh, West, Wiita, Wilcox, Williams, Xie, Xie, Yago, Yan, Yersin, Yoshimori, Yuan, Zhu, Ziegler   +152 more
core   +1 more source

Single-molecule studies of disulfide bond reduction pathways used by human thioredoxin [PDF]

, 2013
Disulfide bond reduction pathways used by human thioredoxin (hTrx) are studied at the single molecule level using a recombinant protein (I27[subscript SS])[subscript 8].
Szoszkiewicz, Robert
core   +1 more source

Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation.

Journal of Organic Chemistry, 2017
Naturally occurring, multiple cysteine-containing peptides are a structurally unique class of compounds with a wide range of therapeutic and diagnostic applications.
Fangzhou Wu, J. Mayer, V. Gelfanov, Fa Liu, R. DiMarchi   +4 more
semanticscholar   +1 more source

Investigating the crucial roles of aliphatic tails in disulfide bond-linked docetaxel prodrug nanoassemblies

Asian Journal of Pharmaceutical Sciences, 2021
Disulfide bond-bridging strategy has been extensively utilized to construct tumor specificity-responsive aliphatic prodrug nanoparticles (PNPs) for precise cancer therapy.
Yuequan Wang, Cong Luo, Shuang Zhou, Xinhui Wang, Xuanbo Zhang, Shumeng Li, Shenwu Zhang, Shuo Wang, Bingjun Sun, Zhonggui He, Jin Sun   +10 more
doaj  

Preventing disulfide bond formation weakens non-covalent forces among lysozyme aggregates. [PDF]

PLoS ONE, 2014
Nonnative disulfide bonds have been observed among protein aggregates in several diseases like amyotrophic lateral sclerosis, cataract and so on. The molecular mechanism by which formation of such bonds promotes protein aggregation is poorly understood ...
Vijay Kumar Ravi, Mohit Goel, Hema Chandra Kotamarthi, Sri Rama Koti Ainavarapu, Rajaram Swaminathan   +4 more
doaj   +1 more source

An ER source for H2O2 [PDF]

, 2015
The endoplasmic reticulum (ER)-localized peroxiredoxin 4 (PRDX4) supports disulfide bond formation in eukaryotic cells lacking endoplasmic reticulum oxidase 1 (ERO1).
Araki, Avezov, Avezov, Belousov, Carlos Lopes, David Ron, Eduardo Pinho Melo, Edward Avezov, Frand, Gross, Gutscher, Hanson, Hudson, Ilir Mehmeti, Iuchi, Lohman, Malinouski, Markvicheva, Mehmeti, Pollard, Sigurd Lenzen, Tasuku Konno, Tavender, Tavender, Tiedge, Tiedge, Tien, Tsai, Tsunoda, van Lith, Zheng, Zito, Zito, Zito   +33 more
core   +3 more sources

A disulfide bond in the TIM23 complex is crucial for voltage gating and mitochondrial protein import

Journal of Cell Biology, 2016
Here, Ramesh et al. show that import and oxidation of Tim17, a membrane-embedded subunit of the mitochondrial protein import machinery, are mediated by the mitochondrial disulfide relay, although its disulfide bond is formed differently than soluble ...
A. Ramesh, V. Peleh, S. Martínez-Caballero, Florian Wollweber, Florian Wollweber, Frederik Sommer, M. Laan, M. Schroda, R. T. Alexander, M. L. Campo, J. Herrmann   +10 more
semanticscholar   +1 more source

In Silico Analysis of Glucose Oxidase from Aspergillus niger: Potential Cysteine Mutation Sites for Enhancing Protein Stability

Bioengineering, 2021
Glucose oxidase (GOx) holds considerable advantages for various applications. Nevertheless, the thermal instability of the enzyme remains a grand challenge, impeding the success in applications outside the well-controlled laboratories, particularly in ...
Sirawit Ittisoponpisan, Itthipon Jeerapan   +1 more
doaj   +1 more source