Results 81 to 90 of about 96,012 (310)

Fine-tuning the activation behaviors of ternary modular cabazitaxel prodrugs for efficient and on-target oral anti-cancer therapy

open access: yesAsian Journal of Pharmaceutical Sciences
The disulfide bond plays a crucial role in the design of anti-tumor prodrugs due to its exceptional tumor-specific redox responsiveness. However, premature breaking of disulfide bonds is triggered by small amounts of reducing substances (e.g., ascorbic ...
Mingyang Zhang   +9 more
doaj   +1 more source

A Van der Waals Optoelectronic Synapse with Tunable Positive and Negative Post‐Synaptic Current for Highly Accurate Spiking Neural Networks

open access: yesAdvanced Functional Materials, EarlyView.
A van der Waals optoelectronic synaptic device based on a ReS2/WSe2 heterostructure and oxygen‐treated h‐BN is presented, which enables both positive and negative PSCs through photocarrier polarity reversal. Bidirectional plasticity arises from gate‐tunable band bending and charge trapping‐induced quasi‐doping.
Hyejin Yoon   +9 more
wiley   +1 more source

DNA‐Templated 2D Heterostructures as Phototriggered Dynamic Nanohybrids: From Releasing Molecular Loads to Controlling Enzyme Biocatalytic Function

open access: yesAdvanced Functional Materials, EarlyView.
DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen   +3 more
wiley   +1 more source

Production and characterization of neurosecretory protein GM using Escherichia coli and Chinese Hamster Ovary cells

open access: yesFEBS Open Bio, 2015
Neurosecretory protein GL (NPGL) and neurosecretory protein GM (NPGM) are paralogs recently discovered in birds and in mammals. The post‐translational products of NPGL and of NPGM genes include a signal peptide sequence, a glycine amidation signal, and a
Keiko Masuda   +4 more
doaj   +1 more source

Alkali Ion‐Incorporated HfO2 Dielectrics for Reconfigurable Neuromorphic Computing

open access: yesAdvanced Functional Materials, EarlyView.
This work presents an indium gallium zinc oxide (IGZO) transistor with an alkali cation‐integrated hafnium dioxide (HfO2) dielectric exhibiting synaptic behavior via ion retention. The solution‐based film fabrication strategy overcomes the limitations of atomic layer deposition (ALD) and precursor coating, enabling the control of synaptic retention ...
Seung Yeon Ki   +7 more
wiley   +1 more source

Electrochemically Driven Dissipative Growth of Affinity Hydrogels for Bioresponsive Interfaces

open access: yesAdvanced Functional Materials, EarlyView.
Voltage pulses drive the growth and reinforcement of hydrogel films under dissipative conditions. This biocompatible strategy enables efficient integration of affinity ligands into the hydrogel matrix, enhancing the selective capture of growth factors and allowing precise temporal control over their release, making them well‐suited as adaptive ...
Roberto Baretta, Marco Frasconi
wiley   +1 more source

Dual‐Functional Li2B4O7 Coating on Carbon Fibers for Enhanced Li+ Transport and Stability in Sulfide All‐Solid‐State Batteries

open access: yesAdvanced Functional Materials, EarlyView.
A dual‐functional Li2B4O7 coating on carbon fibers is designed to resolve the critical interfacial degradation in sulfide all‐solid‐state batteries. The conformal layer acts as a physical barrier to suppress parasitic reactions while its unique dielectric properties simultaneously facilitate Li+ transport.
Yeonghoon Kim   +5 more
wiley   +1 more source

Proteins, Processing, and Properties of Adhesive Fluid Condensates Purified from Mussels

open access: yesAdvanced Functional Materials, EarlyView.
Mussels exhibit an unmatched proficiency for adhering to wet surfaces in salty environments—a remarkable ability that could inspire new biomedical and technical glues. The fluid protein condensates used to form the underwater mussel glue are extracted, reconstituted and characterized with advanced spectroscopy and nanomechanical analysis, revealing ...
Mathieu D. Rivard   +8 more
wiley   +1 more source

Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress

open access: yesScientific Reports, 2017
Based on the oxidative stress theory, aging derives from the accumulation of oxidized proteins induced by reactive oxygen species (ROS) in the cytoplasm.
Ching-Ying Wu   +11 more
doaj   +1 more source

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