Results 81 to 90 of about 16,675 (216)

Exposure to disulfiram and incidence of parkinsonism

Journal of Occupational Medicine and Toxicology
Background Case reports implicate disulfiram treatment in causing parkinsonism, but these observations lack epidemiological confirmation. Aim of the present study was to estimate the risk of incident parkinsonism associated with disulfiram dispensing in ...
Angelo d’Errico, Elena Strippoli, Samuel M. Goldman, Paul D. Blanc   +3 more
doaj   +1 more source

The anti-alcohol dependency drug disulfiram inhibits the viability and progression of gastric cancer cells by regulating the Wnt and NF-κB pathways

Journal of International Medical Research, 2020
Objective Disulfiram is commonly used for alcohol abuse; however, recent studies have revealed its potential as an anti-cancer treatment. This study investigated the effects of disulfiram on gastric cancer and its underlying mechanisms of action. Methods
Jun Zhang, Ke Pu, Suyang Bai, Yukui Peng, Fan Li, Rui Ji, Qinghong Guo, Weiming Sun, Yuping Wang   +8 more
doaj   +1 more source

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source

Experiences of a Pre‐Treatment Sober Month in Individuals With Alcohol Use Disorder Pursuing Controlled Drinking Goals

Drug and Alcohol Review, Volume 45, Issue 5, July 2026.
ABSTRACT Introduction Interest in managing alcohol‐related risks through temporary abstinence challenges has grown significantly. Studies on abstinence challenges in the general population show improvements in for example mental health, blood pressure, insulin resistance and alcohol consumption, but studies in clinical samples are lacking, including ...
Stina Ingesson‐Hammarberg, Sara Wallhed Finn, Anders Hammarberg, Magnus Johansson, Sven Andréasson, Christina Nehlin   +5 more
wiley   +1 more source

Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases

MedComm, Volume 7, Issue 6, June 2026.
Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu, Lin Jia, Kerong Wu, Mo Chen, Jichao Sun, Chuanbin Yang, Chengchao Xu, Jie Sun, Jigang Wang, Lingyun Dai   +9 more
wiley   +1 more source

Disulfiram induces redox imbalance and perturbations in central glucose catabolism and metal homeostasis to inhibit the growth of Staphylococcus aureus

Scientific Reports
Disulfiram (Antabuse®) is a prescription alcohol sobriety aid that has shown repurposing potential as an antibacterial drug for infections due to Gram-positive bacteria.
Timothy E. Long, Surya Teja Naidu, Emily G. Hissom, Yogesh Meka, Hasitha Chavva, Kathleen C. Brown, Meagan E. Valentine, Jun Fan, James Denvir, Donald A. Primerano, Hongwei D. Yu, Monica A. Valentovic   +11 more
doaj   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Desperate measures of involuntary deaddiction: A case report of acute disulfiram poisoning

Kerala Journal of Psychiatry
Disulfiram is an effective deterrent drug for alcohol use in patients who have undergone detoxification and who are motivated to remain abstinent. Disulfiram poisoning is not common; only a few cases have been reported in the literature.
Nanma Livingstone, Arya Jith
doaj   +1 more source

Peptide binding at the gasdermin D exosite reveals the structural basis for targeting the site

Acta Crystallographica Section D, Volume 82, Issue 6, Page 615-625, June 2026.
We describe the first structure of gasdermin D with a putative caspase inhibitor peptide analog at 1.6 Å resolution. This work suggests potential druggability of gasdermin D at the exosite by leveraging structure‐based computational design with biochemical characterization.Gasdermin D (GSDMD) has been identified as a critical component of the ...
Renjing Wang, Thu Ho, Aimie Ogawa, Kartika Widjaja, Zachary Brown, Song Yang, Pei Huo, Michael C. Gregory, Aman Singh, Senthil Perumal, Songnian Lin, Alan C. Cheng, Lindsay S. Garrenton, James Mu, Anthony Ogawa, Jill E. Chrencik   +15 more
wiley   +1 more source

Mechanism of action of disulfiram and research advances in anti-glomerular basement membrane type glomerulonephritis

Linchuang shenzangbing zazhi
Disulfiram is widely applied for treating chronic alcoholism. In recent years, researchers have proposed specific anti-cancer mechanisms by disulfiram, such as arresting the activity of acetaldehyde dehydrogenase （ALDH） and boosting intracellular ...
Yan-yu Zhang, Xin Lyu, Xiao-guang Huang, Xiao-jun Ren, Xue Wang, Wei-min Yu   +5 more
doaj   +1 more source