Identification of Copy Number Variants as a Suspected Cause of Cerebral Small Vessel Disease
Clinical Genetics, EarlyView.Whole‐exome sequencing of 111 patients with suspected familial cerebral small vessel disease (CSVD) identified novel copy number variants in four patients across NOTCH3, LMNB1, and COL4A2, using bioinformatic and molecular techniques. These validated CNVs suggest structural variation is an underrecognized potential causal contributor to monogenic CSVD ...
Solomon K. Guyler +5 more
wiley +1 more source
APPLICATION OF POWDER HIGH-SPEED STEEL AS ANTIFRICTION MATERIAL
Литьë и металлургия, 2011 The influence of disulphide molybdenum additives on antifriction characteristics of powder high-speed steel produced by means of hot hydrostatic pressing is investigated.
M. Beznak, A. S. Chaus
doaj +3 more sources
Revista CientíficaThis study evaluated thiol/disulphide homeostasis and its relationship with oxidative stress in cats diagnosed with feline coronavirus infection.
Melek Aydemir Hökelekli +5 more
doaj +1 more source
Effects of Diaceto-Dipropyl-Disulphide on Plasma Sialic Acid and Renal Tissue Thiol Levels in Alloxan Diabetic Rats [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Plasma sialic acid levels are elevated in Diabetes Mellitus (DM) patients with proteinuria. Renal damage is mainly caused by free radicals that are excessively generated in DM. Thiols play an important role in the cellular antioxidative
Vijay Venkataiah +4 more
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PEG400 regulates Falcipain 2 activity through an allosteric mechanism
The FEBS Journal, EarlyView.Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath +2 more
wiley +1 more source
DISULPHIDE LOCKING: CONTRASTING EFFECTS ON DISPARATE PROTEINS
, 2021 This thesis details a series of structural and biophysical studies on two different proteins containing disulphide bonds: (1) soricidin and (2) engineered mutants of aciniform spider silk.
Sulekha, Anamika
core +1 more source
Thiol/disulphide homeostasis, ischemia modified albumin, and ferroxidase as oxidative stress markers in women with obesity with insulin resistance [PDF]
Journal of Medical Biochemistry, 2019 Background: The purpose of the study was to determine oxidative stress-related plasma thiol/disulphide, ischemiamodified albumin (IMA) levels and ferroxidase activity among women with obesity in insulin-resistant and noninsulin-resistant groups in ...
Ates Elif +4 more
doaj
CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems
The FEBS Journal, EarlyView.Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén +11 more
wiley +1 more source
Periodontal Health and Salivary Thiol-Disulphide Homeostasis in Multiple Sclerosis Patients
Süleyman Demirel Üniversitesi Tıp Fakültesi DergisiObjective: Multiple sclerosis (MS) is a chronic autoimmune disease in which neuroinflammation and oxidative stress play important roles in its pathology.
Fatma Yeşim Kırzıoğlu +5 more
doaj +1 more source
Exciton diamagnetic shifts and valley Zeeman effects in monolayer WS2 and MoS2 to 65 Tesla
Nature Communications, 2016 The spin and valley degrees of freedom are coupled in two-dimensional transition-metal dichalcogenides. Here, the authors use high magnetic fields to optically measure the valley Zeeman effect and diamagnetic exciton shift in tungsten disulphide and ...
Andreas V. Stier +4 more
doaj +1 more source