Results 51 to 60 of about 36,081 (257)

De Novo Design of Multivalent α/β‐Peptides Mimicking Transcription Factors Targeting the CBP KIX Domain

Chemistry – A European Journal, EarlyView.
A modular, de novo α/β‐peptide design strategy allows fine‐tuning of ligand properties, resulting in multivalent ligands that simultaneously target separate binding sites on the protein surface. ABSTRACT Protein‐protein interactions that regulate gene expression in the nucleus are increasingly recognized as potential therapeutic targets but present ...
Márk V. Tresztián, Vencel L. Petrovicz, Edit Wéber, Tamás A. Martinek, Zsófia Hegedüs   +4 more
wiley   +1 more source

Three-dimensional architectures composed of two-dimensional atomic layer molybdenum disulphide for solar cell and self-powered photodetectors with improved performance

Energy Exploration & Exploitation, 2022
Research in the physical sciences is critical to the development of new materials technologies for clean energy. Aims in the present work are to synthesise and characterise three-dimensional architectures composed of two-dimensional atomic layer ...
Ali Aldalbahi, Tansir Ahamad, Saad M Alshehri, Zhen-Bo Wang, Peter X. Feng   +4 more
doaj   +1 more source

The disulphide cleavage derivative (C42-4) of 11′-deoxyverticillin A (C42) fails to induce apoptosis and genomic instability in HeLa cells

Mycology, 2023
Our previous study revealed 11’-deoxyverticillin A (C42), a natural product isolated from the Ophiocordyceps-associated fungus Clonostachys rogersoniana and a member of the epipolythiodioxopiperazines (ETPs), induced both apoptosis and autophagy in ...
Bolin Hou, Huaiyi Yang, Erwei Li, Xuejun Jiang   +3 more
doaj   +1 more source

On the Planarity of Heterocyclic Bay‐Substituted Perylenediimides: Insight into the Fluorescent Photoinduced Electron Transfer Sensing Framework

European Journal of Organic Chemistry, EarlyView.
Near‐infrared fluorescent pH indicators based on perylenediimide were constructed in a modular receptor–spacer–fluorophore–spacer–receptor format with heterocyclic amino moieties at the bay positions. Counterintuitively, the dibrominated intermediate with two heavy atoms is more emissive than the heterocyclic compounds.
Luke Camenzuli, Davide Benedetto Tiz, Nicola’ Agius, Konrad Szaciłowski, David C. Magri   +4 more
wiley   +1 more source

Testican‐1‐MMP axis in tumour extracellular matrix (ECM) remodelling: interaction dynamics analysis and an in silico perspective

The Journal of Pathology, EarlyView.
Abstract The extracellular matrix (ECM) plays a pivotal role in facilitating tumour development, invasiveness, metastasis, and immunoevasive processes through dynamic ECM remodelling processes. Testican‐1 (SPOCK1), an excretory matricellular proteoglycan, is suggested to exert a role in the facilitation of ECM remodelling processes through interacting ...
Sepideh Youssefi, Kiarash Saleki, Prerna Kadam, Amirreza Mazloomi, Abhik Mukherjee, Lodewijk V Dekker, Abdolrahman S Nateri   +6 more
wiley   +1 more source

Evaluation of thiol/disulphide homeostasis as a novel predictor testing tool of early pregnancy viability

Taiwanese Journal of Obstetrics & Gynecology, 2018
Objective: To evaluate serum dynamic thiol/disulphide concentrations in patients with suspected missed abortion (MA) and to determine whether this ratio has a predictive role in the viability in these pregnancies.
Hatice Akkaya, Gülsüm Uysal, Barış Büke, Gamze Gök, Özcan Erel, Çiğdem Karakükçü   +5 more
doaj   +1 more source

Corrosion Failure Analysis of Contactor Type Electrical Connection Components Used in Converter Valve Side Bushings

High Voltage, EarlyView.
ABSTRACT As a commonly used bushing current‐carrying structure in recent years, contactor‐type electrical connection parts operate in a complex environment of electric, thermal and chemical corrosion for extended periods. With the increase of ultra‐high voltage (UHV) transmission capacity, its operating environment faces more stringent challenges, and ...
Qingyu Wang, Tao Xie, Shoufeng Jin, Huidong Tian, Xiaoyu Zhou, Shifeng Shi, Kanghang He, Juzhen Wu, Peng Liu, Zongren Peng   +9 more
wiley   +1 more source

The immune‐related, TGA1 redox‐switch: to be or not to be?

, 2020
New Phytologist, EarlyView.
Yuan Li, Gary J. Loake
wiley   +1 more source

Active sites and thermostability of a non-specific nuclease from Yersinia enterocolitica subsp. palearctica by site-directed mutagenesis

Biotechnology & Biotechnological Equipment, 2018
To identify the amino acid residues that are the critical factors contributing to the high catalytic activity and good thermostability of Yersinia enterocolitica subsp. palearctica non-specific nuclease (Y.
Yu Zhang, Tao Chen, Wei Zheng, Zhen Hua Li, Rui-Feng Ying, Zhen-Xing Tang, Lu-E Shi   +6 more
doaj   +1 more source

Changes in Serum Thiol-Disulphide Homeostasis in Sheep with Gastrointestinal Nematodes

Animals, 2021
This work aimed to evaluate the thiol-disulphide homeostasis in serum of lambs naturally infected by gastrointestinal nematodes presenting different levels of parasite load indirectly indicated by faecal worm egg counts (EPG).
Elizabeth Moreira dos Santos Schmidt, Daniele Floriano Fachiolli, Raphaela Moreira de Oliveira, Fabiana Alves Almeida, Cristiano Magalhães Pariz, Paulo Roberto de Lima Meirelles, Ciniro Costa, Asta Tvarijonaviciute, Ozcan Erel, Salim Neselioglu, Jose Joaquin Ceron, Camila Peres Rubio   +11 more
doaj   +1 more source