Mapping of the ligand-binding site on the b ' domain of human PDI: interaction with peptide ligands and the x-linker region [PDF]
, 2009 PDI (protein disulfide-isomerase) catalyses the formation of native disulfide bonds of secretory proteins in the endoplasmic reticulum. PDI consists of four thioredoxin-like domains, of which two contain redox-active catalytic sites (a and a'), and two ...
Freedman, R. B. +15 more
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Assessment of Thiol/Disulphide Homeostasis in Patients with Knee Osteoarthritis
, 2021 Our aim was to explore the thiol/disulphide homeostasis and the link with functional status in patients who have knee OA. Sixty knee OA patients and 50 healthy individuals were enrolled in this study. We measured serum levels of native thiol, total thiol
Beyazal, Munevver Serdaroglu +3 more
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Microbial Cell Factories, 2019 Background Bacterial secretory proteins often require the formation of disulphide bonds outside the cell to acquire an active conformation. Thiol-disulphide oxidoreductases are enzymes that catalyse the formation of disulphide bonds.
Sonia Gullón +2 more
doaj +1 more source
The effects of ozone on bacterial growth and thiol-disulphide homeostasis in vascular graft infection caused by MRSA in rats [PDF]
Acta Cirúrgica Brasileira, 2017 : Purpose: To investigate the microbiological, inflammatory and oxidant effects of adjuvant ozone administration in experimental rat vascular graft infection model which has not been previously investigated.
Barcin Ozturk +6 more
doaj +2 more sources
Selective loss of cysteine residues and disulphide bonds in a potato proteinase inhibitor II family. [PDF]
PLoS ONE, 2011 Disulphide bonds between cysteine residues in proteins play a key role in protein folding, stability, and function. Loss of a disulphide bond is often associated with functional differentiation of the protein.
Xiu-Qing Li +2 more
doaj +1 more source
Assessing the Evolutionary Conservation of Protein Disulphide Bonds
, 2019 Studying the evolutionary conservation of proteins can be a valuable tool for understanding its function. At the sequence level, the conservation of each residue can be used to infer the importance of the particular regions of proteins.
Wong, WHJ
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The role of oxidative stress in onychomycosis: Thiol/disulphide homeostasis
, 2021 Objectives Onychomycosis is the general term to define fungal nail infections that arise from dermatophytes, non-dermatophytic moulds and yeasts. Thiol/disulphide homeostasis is a new indicator of oxidative stress.
Erel, Özcan +13 more
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Mechanisms of protein disulphide isomerase catalyzed disulphide bond formation [PDF]
, 2010 Protein folding of outer membrane and secreted proteins, including receptors, cytokines and antibodies is often linked to disulphide bond formation. Native disulphide bond formation is complex and is usually the rate limiting step in the folding of such ...
Lappi, A.-K. (Anna-Kaisa)
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Evaluation of Dynamic Thiol-Disulphide Homeostasis in Patients with Epilepsy
, 2016 Objectives:The aim of this study was to investigate dynamic thiol-disulphide homeostasis as a novel oxidative stress parameter in patients with epilepsy.Methods:A total of 100 participants were included in the study.
Gönül VURAL +5 more
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Haseki Tıp Bülteni, 2021 Aim:Positron emission tomography/computerized tomography (PET/CT) is used for oncologic imaging as hybrid imaging. Pediatric patients are exposed to ionizing radiation when they undergo hybrid medical imaging examinations.
Nilgun Eroglu +7 more
doaj +1 more source