Results 41 to 50 of about 41,368 (245)

Chemical Strategies for Multistimuli Responsive Dynamic Covalent Materials in Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
Multistimuli responsive dynamic covalent materials integrate reversible chemistry with the complex chemical, mechanical, and biochemical cues of regenerative environments. This review highlights chemical strategies based on orthogonal dynamic bonds, multicomponent networks, and hierarchical architectures to regulate mechanics, degradation, and ...
Saurabh Joshi, Matthew B. Baker, Dominik Schauenburg   +2 more
wiley   +1 more source

DisCoTune: versatile auxiliary plasmids for the production of disulphide‐containing proteins and peptides in the E. coli T7 system

Microbial Biotechnology, 2021
Summary Secreted proteins and peptides hold large potential both as therapeutics and as enzyme catalysts in biotechnology. The high stability of many secreted proteins helps maintain functional integrity in changing chemical environments and is a ...
Andreas B. Bertelsen, Celeste Menuet Hackney, Carolyn N. Bayer, Lau D. Kjelgaard, Maja Rennig, Brian Christensen, Esben Skipper Sørensen, Helena Safavi‐Hemami, Tune Wulff, Lars Ellgaard, Morten H. H. Nørholm   +10 more
doaj   +1 more source

Intramolecular disulphide bond arrangements in nonhomologous proteins

, 2005
The presence and location of intramolecular disulphide bonds are a key determinant of the structure and function of proteins. Intramolecular disulphide bonds in proteins have previously been analyzed under the assumption that there is no clear ...
Hartig, Gerald R. S., Tran, Tran T., Smythe, Mark L.   +2 more
core   +1 more source

Dynamic thiol and disulphide homoeostasis in fibromyalgia

, 2020
Introduction: Thiol and disulphide levels are biomarkers that provide useful information about oxidative stress and antioxidant capacity, showing a different homoeostasis in inflammatory and proliferative diseases.
Karatas, Gulsah, Haskul, Ismail, Ustun, Betul, Karatas, Fatih, Neselioglu, Salim, Gunduz, Ramazan, Akyuz, Mufit   +6 more
core   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

The unique cysteine knot regulates the pleotropic hormone leptin. [PDF]

PLoS ONE, 2012
Leptin plays a key role in regulating energy intake/expenditure, metabolism and hypertension. It folds into a four-helix bundle that binds to the extracellular receptor to initiate signaling.
Ellinor Haglund, Joanna I Sułkowska, Zhao He, Gen-Sheng Feng, Patricia A Jennings, José N Onuchic   +5 more
doaj   +1 more source

Three-dimensional architectures composed of two-dimensional atomic layer molybdenum disulphide for solar cell and self-powered photodetectors with improved performance

Energy Exploration & Exploitation, 2022
Research in the physical sciences is critical to the development of new materials technologies for clean energy. Aims in the present work are to synthesise and characterise three-dimensional architectures composed of two-dimensional atomic layer ...
Ali Aldalbahi, Tansir Ahamad, Saad M Alshehri, Zhen-Bo Wang, Peter X. Feng   +4 more
doaj   +1 more source

Immunological Cross-Reactivity and Neutralizing Efficacy of Antivenom Against Five Medically Important Iranian Viper Venoms. [PDF]

Vet Med Sci
Investigating Iranian viper venoms reveals compositional and antigenic diversity impacting antivenom efficacy. The study highlights the need to incorporate both broadly cross‐reactive and specifically under‐represented venoms into immunization mixtures to optimize paraspecific protection strategies.
Khamehchian S, Tahoori F, Rabie H, Nasrabadi NN, Tebianian M.   +4 more
europepmc   +2 more sources

Carbon disulphide promotes sprouting of potato minitubers [PDF]

, 2010
We investigated the effects of postharvest application of carbon disulphide (CS2) in various concentrations (0, 15, 25, 35, 45 and 55 ml m-3) and with different exposure duration (24, 48, 72 and 96 h) on breaking of dormancy and sprouting of potato ...
Salimi, Kh., Tavakkol Afshari, R., Hosseini, M.B., Struik, P.C.   +3 more
core  

The disulphide cleavage derivative (C42-4) of 11′-deoxyverticillin A (C42) fails to induce apoptosis and genomic instability in HeLa cells

Mycology, 2023
Our previous study revealed 11’-deoxyverticillin A (C42), a natural product isolated from the Ophiocordyceps-associated fungus Clonostachys rogersoniana and a member of the epipolythiodioxopiperazines (ETPs), induced both apoptosis and autophagy in ...
Bolin Hou, Huaiyi Yang, Erwei Li, Xuejun Jiang   +3 more
doaj   +1 more source