Results 31 to 40 of about 485 (159)

Optimising migraine treatment: from drug-drug interactions to personalized medicine

The Journal of Headache and Pain, 2019
Migraine is the most disabling and expensive chronic disorders, the etiology of which is still not fully known. The neuronal systems, (glutammatergic, dopaminergic, serotoninergic and GABA-ergic) whose functionality is partly attributable to genetically ...
Leda Marina Pomes, Martina Guglielmetti, Enrico Bertamino, Maurizio Simmaco, Marina Borro, Paolo Martelletti   +5 more
doaj   +1 more source

Ten Minutes with Dr Linghang Wang, Director of Infectious Diseases Emergency, Deputy Director of the Research Institute of Infectious Diseases, Beijing Ditan Hospital [PDF]

BMJ Leader, 2020
### Biography Dr Linghang Wang, MD PhD, is Director of Infectious Diseases Emergency, and Deputy Director of the Research Institute of Infectious Diseases, at Beijing Ditan Hospital, Capital Medical University, Beijing, China. He has been working as a clinical doctor in Beijing Ditan Hospital since 1998.
Linghang, Wang, Anthony, Berendt
openaire   +2 more sources

The HuoXue DiTan Recipe Attenuates Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats by Increasing Autophagy Through the PTEN/PI3K/AKT/mTOR Pathway [PDF]

, 2021
Abstract Background Hypertension-induced left ventricular hypertrophy (LVH) is associated with a reduction in autophagy, which can be inhibited by disruption of the PTEN/PI3K/AKT/mTOR pathway. The HuoXue DiTan recipe (HDR) is a commonly used prescription that has shown therapeutic effects on hypertension and its complications.
YAO Jiamei, ZHANG Cui, YANG Yushu, YANG Haiyan, ZHANG Dan, SHI Yongyue, CHEN Qiong, Guangwei Zhong   +7 more
openaire   +1 more source

Pharmacological Management of Acute Migraine: A Systematic Review Comparing NSAIDs, Triptans, Gepants, and Opioids

Journal of Education, Health and Sport
Background. Migraine is a complex neurobiological disorder associated with the activation of the trigeminovascular system. Many new publications about new drugs appear, but not all of them assign the drug to the most appropriate group of patients ...
Wiktor Kowalczyk, Weronika Olech, Julia Kępska, Aneta Synakiewicz, Natalia Lewińska, Aleksandra Pociej, Arina Drobashko, Nikola Murawska, Kamil Wójcik, Nicole Bulińska   +9 more
doaj   +1 more source

Lasmiditan as the First and Only Representative of a New Class of Neuroactive Anti-Migraine Medications: A Review

Безопасность и риск фармакотерапии
INTRODUCTION. Lasmiditan, a new selective 5-HT1F receptor agonist (approved by FDA in 2019), relieves migraine attacks via neuronal inhibition and acts in the central and peripheral nervous systems.
I. A. Mazerkina, R. N. Alyautdin
doaj   +1 more source

Underrecognized Q fever and rickettsial diseases across China

iMetaOmics, EarlyView.
Q fever and rickettsial diseases are underrecognized causes of fever of unknown origin in China, with Coxiella burnetii and Orientia tsutsugamushi predominating. We identify Rickettsia bellii‐like sequences in human clinical specimens and highlight unexpected pediatric detections that warrant further investigation of possible exposure patterns ...
Tian Qin, Zhongqiu Teng, Yamin Sun, Yaoming Liang, Junrong Liang, Ronghua Jin, Jianguo Xu   +6 more
wiley   +1 more source

subtypes

, 2021
5-hydroxytryptamine (5-HT; serotonin) is traditionally considered as a key mediator implicated in migraine. Multiple 5-HT receptor subtypes contribute to a variety of region-specific functional effects.
Rashid Giniatullin, Giniatullin, Rashid
core   +1 more source

Lactate and Lactylation: What We Know and What We Expect in Tumour Progression

Cell Proliferation, EarlyView.
Lactate and lactylation in cancer cells have been shown to accelerate tumour development in various ways, including stemness generation, metabolic dysregulation, cell death, chemotherapy resistance, and cell cycle disorder. In addition, lactate and lactylation promote angiogenesis and create an immunosuppressive microenvironment, which promotes tumour ...
Qi Zhang, Zhenzhen Han, Youjia Duan
wiley   +1 more source

Is selective 5-HT1F receptor agonism an entity apart from that of the triptans in antimigraine therapy? [PDF]

, 2018
Migraine is a neurovascular disorder that involves activation of the trigeminovascular system and cranial vasodilation mediated by release of calcitonin gene-related peptide (CGRP).The gold standard for acute migraine treatment are the triptans, 5-HT1B ...
Carlos M. Villalón, Antoinette MaassenVanDenBrink, Maassen van den Brink, A. (Antoinette), Eloísa Rubio-Beltrán, Maassen van den Brink, Antoinette, Rubio-Beltrán, Eloísa, Villalon, CM, Alejandro Labastida-Ramírez, Villalón, Carlos M., Labastida-Ramirez, A, Rubio-Beltrán, Eloísa; id_orcid, Villalón, Carlos M, Labastida-Ramírez, Alejandro, MaassenVanDenBrink, Antoinette, Labastida-Ramírez, Alejandro; id_orcid, Rubio-Beltran, E, Labastida-Ramírez, A. (Alejandro), Rubio-Beltrán, E. (Eloísa), Villalón, C.M. (Carlos)   +18 more
core   +1 more source

Real‐world outcomes of zavegepant use in a tertiary care setting using the Migraine Treatment Optimization Questionnaire‐5

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background The introduction of calcitonin gene‐related peptide antagonists has transformed migraine care. Zavegepant, a third‐generation intranasal gepant, offers a nonoral treatment option for acute migraine. Although clinical trials support its efficacy and safety, real‐world data are limited.
Eric Dunn, Bradley Ong, Harpreet Kaur, Roman Popov, Claire Sonneborn, Aarushi Suneja   +5 more
wiley   +1 more source